Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Increased serum brain-derived neurotrophic factor (BDNF) levels in patients with narcolepsy

Research output: Contribution to journalJournal articleResearchpeer-review

  1. DNA methylation regulates CHRNA7 transcription and can be modulated by valproate

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Increased oxidation of RNA despite reduced mitochondrial respiration after chronic electroconvulsive stimulation of rat brain tissue

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Acetazolamide lowers intracranial pressure and modulates the cerebrospinal fluid secretion pathway in healthy rats

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. An oral NaV1.8 blocker improves motor function in mice completely deficient of myelin protein P0

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Serotonergic projections from the raphe nuclei to the subthalamic nucleus; a retrograde- and anterograde neuronal tracing study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Long-term health and socioeconomic consequences of childhood and adolescent-onset of narcolepsy

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. The role of sleep in the pathophysiology of nocturnal enuresis

    Research output: Contribution to journalReviewResearchpeer-review

  3. CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations
Narcolepsy is a lifelong sleep disorder characterized by excessive daytime sleepiness, sudden loss of muscle tone (cataplexy), fragmentation of nocturnal sleep and sleep paralysis. The symptoms of the disease strongly correlate with a reduction in hypocretin levels in CSF and a reduction in hypocretin neurons in hypothalamus in post-mortem tissue. Brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) are important for activity-dependent neuronal function and synaptic modulation and it is considered that these mechanisms are important in sleep regulation. We hypothesized that serum levels of these factors are altered in patients with narcolepsy compared to healthy controls without sleep disturbances. Polysomnography data was obtained and serum BDNF and NGF levels measured using ELISA, while hypocretin was measured using RIA. Serum BDNF levels were significantly higher in narcolepsy patients than in healthy controls (64.2±3.9 ng/ml vs. 47.3±2.6 ng/ml, P
Original languageEnglish
JournalNeuroscience Letters
Volume544
Pages (from-to)31-5
Number of pages5
ISSN0304-3940
DOIs
Publication statusPublished - 7 Jun 2013

    Research areas

  • Adult, Aged, Body Mass Index, Female, Humans, Intracellular Signaling Peptides and Proteins, Male, Middle Aged, Narcolepsy, Nerve Growth Factors, Neuropeptides, Reproducibility of Results, Sensitivity and Specificity

ID: 42577051