Abstract
Endothelin-1 (ET-1) is recognized as being involved in the pathophysiology of cerebrovascular diseases. Using organ culture as a model for possible pathological changes we studied changes in ET(A) and ETB receptor function using a sensitive in vitro method. We observed an up-regulation of the ET(B) receptor and an amazingly increased sensitivity to ET-1 by 3 log units in pEC50; pEC50(fresh) was 8.7 +/- 0.1, and pEC50(cultured) was 11.7 +/- 0.3. pA2 for FR139317 in the fresh vessel was 7.0 +/- 0.2 whereas it could not be obtained for the cultured vessel, indicating a possible cross-talk between the ET(A) and ET(B) receptors. The increased sensitivity to ET-1 could also take place during cerebrovascular disease such as stroke or haemorrhage rendering the vessels considerably more sensitive to ET-1.
| Original language | English |
|---|---|
| Journal | NeuroReport |
| Volume | 11 |
| Issue number | 3 |
| Pages (from-to) | 649-52 |
| Number of pages | 4 |
| ISSN | 0959-4965 |
| Publication status | Published - 28 Feb 2000 |
Keywords
- Animals
- Azepines
- Basilar Artery
- Biphenyl Compounds
- Dipeptides
- Endothelin Receptor Antagonists
- Endothelin-1
- Indoles
- Organ Culture Techniques
- Rats
- Rats, Inbred WKY
- Receptor, Endothelin A
- Receptor, Endothelin B
- Receptors, Endothelin
- Vasoconstriction
- Vasoconstrictor Agents
- Viper Venoms
Fingerprint
Dive into the research topics of 'Increased sensitivity to ET-1 in rat cerebral arteries following organ culture'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS