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Increased self-diffusion of brain water in normal aging.

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Harvard

Gideon, P, Thomsen, C & Henriksen, O 1994, 'Increased self-diffusion of brain water in normal aging.' Journal of Magnetic Resonance Imaging, vol. 4, no. 2, pp. 185-188.

APA

Gideon, P., Thomsen, C., & Henriksen, O. (1994). Increased self-diffusion of brain water in normal aging. Journal of Magnetic Resonance Imaging, 4(2), 185-188.

CBE

MLA

Vancouver

Author

Gideon, P ; Thomsen, C ; Henriksen, O. / Increased self-diffusion of brain water in normal aging. In: Journal of Magnetic Resonance Imaging. 1994 ; Vol. 4, No. 2. pp. 185-188.

Bibtex

@article{1af3bf07a5d9417d940bafa3f9f4856e,
title = "Increased self-diffusion of brain water in normal aging.",
abstract = "With magnetic resonance (MR) imaging, brain water self-diffusion was measured in 17 healthy volunteers 22-76 (mean, 44.6) years old. The calculated values for the apparent diffusion coefficients (ADCs) ranged from 0.58 x 10(-9) to 1.23 x 10(-9) m2/sec in cerebral white matter. A significant correlation was found between the ADC in white matter and age (r = .7069, P < .01). The calculated values for ADC in cortical gray matter ranged from 1.06 x 10(-9) to 1.72 x 10(-9) m2/sec; no correlation was found between ADCs in gray matter and age. The increased ADC in white matter may be caused by an increase in the extracellular volume due to age-dependent neuronal degeneration or to changes in myelination. These findings have implications for future clinical investigations with diffusion MR imaging techniques in patients with neurologic diseases, and stress the importance of having an age-matched group of healthy volunteers for comparison.",
author = "P Gideon and C Thomsen and O Henriksen",
year = "1994",
language = "English",
volume = "4",
pages = "185--188",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John/Wiley & Sons, Inc. John/Wiley & Sons Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Increased self-diffusion of brain water in normal aging.

AU - Gideon, P

AU - Thomsen, C

AU - Henriksen, O

PY - 1994

Y1 - 1994

N2 - With magnetic resonance (MR) imaging, brain water self-diffusion was measured in 17 healthy volunteers 22-76 (mean, 44.6) years old. The calculated values for the apparent diffusion coefficients (ADCs) ranged from 0.58 x 10(-9) to 1.23 x 10(-9) m2/sec in cerebral white matter. A significant correlation was found between the ADC in white matter and age (r = .7069, P < .01). The calculated values for ADC in cortical gray matter ranged from 1.06 x 10(-9) to 1.72 x 10(-9) m2/sec; no correlation was found between ADCs in gray matter and age. The increased ADC in white matter may be caused by an increase in the extracellular volume due to age-dependent neuronal degeneration or to changes in myelination. These findings have implications for future clinical investigations with diffusion MR imaging techniques in patients with neurologic diseases, and stress the importance of having an age-matched group of healthy volunteers for comparison.

AB - With magnetic resonance (MR) imaging, brain water self-diffusion was measured in 17 healthy volunteers 22-76 (mean, 44.6) years old. The calculated values for the apparent diffusion coefficients (ADCs) ranged from 0.58 x 10(-9) to 1.23 x 10(-9) m2/sec in cerebral white matter. A significant correlation was found between the ADC in white matter and age (r = .7069, P < .01). The calculated values for ADC in cortical gray matter ranged from 1.06 x 10(-9) to 1.72 x 10(-9) m2/sec; no correlation was found between ADCs in gray matter and age. The increased ADC in white matter may be caused by an increase in the extracellular volume due to age-dependent neuronal degeneration or to changes in myelination. These findings have implications for future clinical investigations with diffusion MR imaging techniques in patients with neurologic diseases, and stress the importance of having an age-matched group of healthy volunteers for comparison.

M3 - Journal article

VL - 4

SP - 185

EP - 188

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 2

ER -

ID: 32497917