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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Increased risk of neonatal complications and infections in children of kidney-transplanted women: A nationwide controlled cohort study

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Information related to short- and long-term risks of children born to kidney-transplanted women remains limited. With the aim of investigating the risk of neonatal complications, and the short- and long-term risk of infections in offspring of kidney-transplanted women, all children born to kidney-transplanted women in Denmark from 1964 to 2016 were identified in a nationwide retrospective matched cohort study. A total of 124 children of kidney-transplanted women were identified and matched on gender, birth year, and number of siblings at birth 1:10 with children born to nontransplanted women identified in the Danish general population. Prevalence of low birth weight (37.9%, risk ratio [RR] = 12.61; 95% confidence interval [CI], 8.5-18.5), premature birth (46.0%, RR = 11.32; 95% CI, 8.1-15.7) and malformations (11.3%, RR = 1.98; 95% CI, 1.2-3.4) was increased in children of kidney-transplanted women compared with controls. Similarly, prevalence of hospitalization due to infection was increased during the first year of life (21.0%, RR = 1.94; 95% CI, 1.3-2.8), from age 1 to 5 (34.2%, RR = 1.89; 95% CI, 1.4-2.5), and overall (41.9%, RR = 1.67; 95% CI, 1.3-2.1). The risk of infection was also higher in children of kidney-transplanted mothers born preterm or with low birth weight compared with similar controls. In conclusion, risk of neonatal complications, malformations, and both early and late infection were increased in children born to kidney-transplanted women.

Original languageEnglish
JournalAmerican Journal of Transplantation
Volume21
Issue number3
Pages (from-to)1171-1178
Number of pages8
ISSN1600-6135
DOIs
Publication statusPublished - Mar 2021

    Research areas

  • clinical research/practice, epidemiology, immunosuppression/immune modulation, immunosuppressive regimens, innate immunity, kidney transplantation/nephrology, obstetrics and gynecology, pregnancy, reproductive biology, practice, kidney transplantation, immunosuppression, nephrology, clinical research, immune modulation

ID: 60682024