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Increased risk of diabetes mellitus five years after an episode of Staphylococcus aureus bacteraemia

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@article{c7bfbf1a621e4608918169c7dcd8d933,
title = "Increased risk of diabetes mellitus five years after an episode of Staphylococcus aureus bacteraemia",
abstract = "BACKGROUND: Diabetes mellitus is a risk factor for infection with Staphylococcus aureus, but it is unclear whether S. aureus infection is a prediabetic condition.METHODS: Nationwide population-based matched cohort study. Incidence rate and ratio with 95{\%} confidence interval of diabetes were estimated by negative binomial regression.RESULTS: Of 19,988 individuals with S. aureus bacteraemia and 185,579 population comparators, 667 and 4974 had a primary diagnose of diabetes within five years after discharge of S. aureus bacteraemia corresponding to a more than double risk of diabetes (adjusted incidence rate ratio 2.28 (95{\%} confidence interval: 2.10-2.46)). Other factors associated with an increased risk of diabetes during follow-up were male sex, increasing age and level of comorbidity. Of the S. aureus bacteraemia and population cohort, 422 (2.11{\%}) and 4048 (2.18{\%}), respectively, developed diabetes without complications, while 245 (1.23{\%}) and 926 (0.50{\%}), respectively, developed diabetes with complications. Rates of diabetes without complication were increased for individuals in the S. aureus bacteraemia cohort compared to the population cohort within the first two years after which rates were comparable while rates of diabetes with complications remained higher throughout the five year follow-up period compared to the population cohort.CONCLUSIONS: The risk of diabetes was markedly increased up to five years after S. aureus bacteraemia compared to a population cohort. In addition to screening for diabetes during hospital admittance, screening cases of S. aureus bacteraemia for diabetes in the years following S. aureus bacteraemia may allow for earlier detection of diabetes.",
keywords = "diabetes mellitus, epidemiology, Staphylococcus aureus bacteraemia",
author = "Marie-Louise Uhre and Nanja Gotland and Haakon Sandholdt and Niels Mejer and Andreas Petersen and {Rhod Larsen}, Anders and Thomas Benfield",
year = "2019",
month = "7",
doi = "10.1080/23744235.2019.1602284",
language = "English",
volume = "51",
pages = "512--518",
journal = "Infectious Diseases",
issn = "2374-4235",
publisher = "Taylor and Francis Ltd.",
number = "7",

}

RIS

TY - JOUR

T1 - Increased risk of diabetes mellitus five years after an episode of Staphylococcus aureus bacteraemia

AU - Uhre, Marie-Louise

AU - Gotland, Nanja

AU - Sandholdt, Haakon

AU - Mejer, Niels

AU - Petersen, Andreas

AU - Rhod Larsen, Anders

AU - Benfield, Thomas

PY - 2019/7

Y1 - 2019/7

N2 - BACKGROUND: Diabetes mellitus is a risk factor for infection with Staphylococcus aureus, but it is unclear whether S. aureus infection is a prediabetic condition.METHODS: Nationwide population-based matched cohort study. Incidence rate and ratio with 95% confidence interval of diabetes were estimated by negative binomial regression.RESULTS: Of 19,988 individuals with S. aureus bacteraemia and 185,579 population comparators, 667 and 4974 had a primary diagnose of diabetes within five years after discharge of S. aureus bacteraemia corresponding to a more than double risk of diabetes (adjusted incidence rate ratio 2.28 (95% confidence interval: 2.10-2.46)). Other factors associated with an increased risk of diabetes during follow-up were male sex, increasing age and level of comorbidity. Of the S. aureus bacteraemia and population cohort, 422 (2.11%) and 4048 (2.18%), respectively, developed diabetes without complications, while 245 (1.23%) and 926 (0.50%), respectively, developed diabetes with complications. Rates of diabetes without complication were increased for individuals in the S. aureus bacteraemia cohort compared to the population cohort within the first two years after which rates were comparable while rates of diabetes with complications remained higher throughout the five year follow-up period compared to the population cohort.CONCLUSIONS: The risk of diabetes was markedly increased up to five years after S. aureus bacteraemia compared to a population cohort. In addition to screening for diabetes during hospital admittance, screening cases of S. aureus bacteraemia for diabetes in the years following S. aureus bacteraemia may allow for earlier detection of diabetes.

AB - BACKGROUND: Diabetes mellitus is a risk factor for infection with Staphylococcus aureus, but it is unclear whether S. aureus infection is a prediabetic condition.METHODS: Nationwide population-based matched cohort study. Incidence rate and ratio with 95% confidence interval of diabetes were estimated by negative binomial regression.RESULTS: Of 19,988 individuals with S. aureus bacteraemia and 185,579 population comparators, 667 and 4974 had a primary diagnose of diabetes within five years after discharge of S. aureus bacteraemia corresponding to a more than double risk of diabetes (adjusted incidence rate ratio 2.28 (95% confidence interval: 2.10-2.46)). Other factors associated with an increased risk of diabetes during follow-up were male sex, increasing age and level of comorbidity. Of the S. aureus bacteraemia and population cohort, 422 (2.11%) and 4048 (2.18%), respectively, developed diabetes without complications, while 245 (1.23%) and 926 (0.50%), respectively, developed diabetes with complications. Rates of diabetes without complication were increased for individuals in the S. aureus bacteraemia cohort compared to the population cohort within the first two years after which rates were comparable while rates of diabetes with complications remained higher throughout the five year follow-up period compared to the population cohort.CONCLUSIONS: The risk of diabetes was markedly increased up to five years after S. aureus bacteraemia compared to a population cohort. In addition to screening for diabetes during hospital admittance, screening cases of S. aureus bacteraemia for diabetes in the years following S. aureus bacteraemia may allow for earlier detection of diabetes.

KW - diabetes mellitus

KW - epidemiology

KW - Staphylococcus aureus bacteraemia

UR - http://www.scopus.com/inward/record.url?scp=85064734337&partnerID=8YFLogxK

U2 - 10.1080/23744235.2019.1602284

DO - 10.1080/23744235.2019.1602284

M3 - Journal article

VL - 51

SP - 512

EP - 518

JO - Infectious Diseases

JF - Infectious Diseases

SN - 2374-4235

IS - 7

ER -

ID: 57026612