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Increased risk of anemia, neutropenia and thrombocytopenia in people with HIV and well-controlled viral replication

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@article{196997589b044335a1a04b7125eefb72,
title = "Increased risk of anemia, neutropenia and thrombocytopenia in people with HIV and well-controlled viral replication",
abstract = "BACKGROUND: Prior to the introduction of combination antiretroviral therapy (cART), cytopenias were common in people with HIV (PWH), but it is unknown if well-controlled HIV infection is a risk factor for cytopenia. In this study we aimed to determine if HIV infection is an independent risk factor for anemia, neutropenia, lymphocytopenia, and thrombocytopenia.METHODS: PWH with undetectable viral replication and absence of chronic hepatitis infection (n=796) were recruited from the Copenhagen Comorbidity in HIV infection (COCOMO) study and matched uninfected controls from the Copenhagen General Population Study (n=2388). Hematology was analyzed in venous blood samples. Logistic regression analyses adjusted for age, sex, ethnicity, smoking status, alcohol, and hs-CRP were performed to determine possible associations between HIV and cytopenias.RESULTS: PWH had a higher prevalence of anemia (6.9{\%} vs. 3.4{\%}, P<.001), neutropenia (1.3{\%} vs. 0.2{\%}, P<.001), and thrombocytopenia (5.5{\%} vs. 2.7{\%}, P<.001) than uninfected controls. HIV was independently associated with anemia adjusted odds ratio (aOR) 2.0 (95{\%}CI: 1.4-3.0), neutropenia aOR 6.3 (95{\%}CI: 2.0-19.6) and thrombocytopenia aOR 2.7 (95{\%}CI: 1.8-4.2). No association was found between HIV and lymphocytopenia.CONCLUSIONS: Cytopenia is rare in PWH and well-controlled virus, but HIV remains a risk factor for anemia, neutropenia and thrombocytopenia and requires ongoing attention and monitoring.",
keywords = "Anemia, Cytopenia, HIV, Lymphocytopenia, Neutropenia, Thrombocytopenia",
author = "Delal Akdag and Knudsen, {Andreas Dehlb{\ae}k} and Thudium, {Rebekka Faber} and Kirkegaard-Klitbo, {Ditte Marie} and Chivit Nielsen and Peter Brown and Shoaib Afzal and Nordestgaard, {B{\o}rge G} and Jens Lundgren and Nielsen, {Susanne Dam}",
note = "{\circledC} The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.",
year = "2019",
month = "10",
day = "22",
doi = "10.1093/infdis/jiz394",
language = "English",
volume = "220",
pages = "1834--1842",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "University of Chicago Press",
number = "11",

}

RIS

TY - JOUR

T1 - Increased risk of anemia, neutropenia and thrombocytopenia in people with HIV and well-controlled viral replication

AU - Akdag, Delal

AU - Knudsen, Andreas Dehlbæk

AU - Thudium, Rebekka Faber

AU - Kirkegaard-Klitbo, Ditte Marie

AU - Nielsen, Chivit

AU - Brown, Peter

AU - Afzal, Shoaib

AU - Nordestgaard, Børge G

AU - Lundgren, Jens

AU - Nielsen, Susanne Dam

N1 - © The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

PY - 2019/10/22

Y1 - 2019/10/22

N2 - BACKGROUND: Prior to the introduction of combination antiretroviral therapy (cART), cytopenias were common in people with HIV (PWH), but it is unknown if well-controlled HIV infection is a risk factor for cytopenia. In this study we aimed to determine if HIV infection is an independent risk factor for anemia, neutropenia, lymphocytopenia, and thrombocytopenia.METHODS: PWH with undetectable viral replication and absence of chronic hepatitis infection (n=796) were recruited from the Copenhagen Comorbidity in HIV infection (COCOMO) study and matched uninfected controls from the Copenhagen General Population Study (n=2388). Hematology was analyzed in venous blood samples. Logistic regression analyses adjusted for age, sex, ethnicity, smoking status, alcohol, and hs-CRP were performed to determine possible associations between HIV and cytopenias.RESULTS: PWH had a higher prevalence of anemia (6.9% vs. 3.4%, P<.001), neutropenia (1.3% vs. 0.2%, P<.001), and thrombocytopenia (5.5% vs. 2.7%, P<.001) than uninfected controls. HIV was independently associated with anemia adjusted odds ratio (aOR) 2.0 (95%CI: 1.4-3.0), neutropenia aOR 6.3 (95%CI: 2.0-19.6) and thrombocytopenia aOR 2.7 (95%CI: 1.8-4.2). No association was found between HIV and lymphocytopenia.CONCLUSIONS: Cytopenia is rare in PWH and well-controlled virus, but HIV remains a risk factor for anemia, neutropenia and thrombocytopenia and requires ongoing attention and monitoring.

AB - BACKGROUND: Prior to the introduction of combination antiretroviral therapy (cART), cytopenias were common in people with HIV (PWH), but it is unknown if well-controlled HIV infection is a risk factor for cytopenia. In this study we aimed to determine if HIV infection is an independent risk factor for anemia, neutropenia, lymphocytopenia, and thrombocytopenia.METHODS: PWH with undetectable viral replication and absence of chronic hepatitis infection (n=796) were recruited from the Copenhagen Comorbidity in HIV infection (COCOMO) study and matched uninfected controls from the Copenhagen General Population Study (n=2388). Hematology was analyzed in venous blood samples. Logistic regression analyses adjusted for age, sex, ethnicity, smoking status, alcohol, and hs-CRP were performed to determine possible associations between HIV and cytopenias.RESULTS: PWH had a higher prevalence of anemia (6.9% vs. 3.4%, P<.001), neutropenia (1.3% vs. 0.2%, P<.001), and thrombocytopenia (5.5% vs. 2.7%, P<.001) than uninfected controls. HIV was independently associated with anemia adjusted odds ratio (aOR) 2.0 (95%CI: 1.4-3.0), neutropenia aOR 6.3 (95%CI: 2.0-19.6) and thrombocytopenia aOR 2.7 (95%CI: 1.8-4.2). No association was found between HIV and lymphocytopenia.CONCLUSIONS: Cytopenia is rare in PWH and well-controlled virus, but HIV remains a risk factor for anemia, neutropenia and thrombocytopenia and requires ongoing attention and monitoring.

KW - Anemia

KW - Cytopenia

KW - HIV

KW - Lymphocytopenia

KW - Neutropenia

KW - Thrombocytopenia

U2 - 10.1093/infdis/jiz394

DO - 10.1093/infdis/jiz394

M3 - Journal article

VL - 220

SP - 1834

EP - 1842

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 11

ER -

ID: 57796923