Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Increased respiratory neural drive and work of breathing in exercise-induced laryngeal obstruction

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Effects of anti-inflammatory (NSAID) treatment on human tendinopathic tissue

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Effects of strict prolonged bed rest on cardiorespiratory fitness: systematic review and meta-analysis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Regulation of blood volume in lowlanders exposed to high altitude

    Research output: Contribution to journalReviewResearchpeer-review

  4. CORP: The assessment of total hemoglobin mass by carbon monoxide rebreathing

    Research output: Contribution to journalReviewResearchpeer-review

  1. Kronisk bihulebetændelse og type 2-sygdom

    Research output: Contribution to journalReviewResearchpeer-review

  2. Automated cell differential count in sputum is feasible and comparable to manual cell count in identifying eosinophilia

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. High Use of Antidepressant Medication in Both Mild-to-Modelate and Possible Severe Asthma - A Nationwide Cohort Study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Airway gene expression identifies subtypes of type 2 inflammation in severe asthma

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Clinical patterns, recovery time and prolonged impact of COVID-19 illness in international athletes: the UK experience

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Rationale: Exercise induced laryngeal obstruction (EILO), a phenomenon in which the larynx closes inappropriately during physical activity, is a prevalent cause of exertional dyspnea in young individuals. The physiological ventilatory impact of EILO and its relationship to dyspnea are poorly understood. Objectives: To evaluate exercise related changes in laryngeal aperture on ventilation, pulmonary mechanics and respiratory neural drive. Methods: We prospectively evaluated 12 subjects (six with EILO and six healthy age- and gender-matched controls). Subjects underwent baseline spirometry and a symptom-limited incremental exercise test with simultaneous and synchronized recording of endoscopic video, gastric-, esophageal- and transdiaphragmatic pressures, diaphragm electromyography and respiratory airflow. Results: The EILO and control groups had similar peak work rates and minute ventilation (V̇E) (work rate: 227±35 vs. 237±35W; V̇E: 103±20 vs. 98±23 L/min; p>0.05). At submaximal work rates (140-240W) subjects with EILO demonstrated increased work of breathing (p<0.05) and respiratory neural drive (p<0.05), developing in close temporal association with onset of endoscopic evidence of laryngeal closure (p<0.05). Unexpectedly, a ventilatory increase (p<0.05), driven by augmented tidal volume (p<0.05), was seen in subjects with EILO, before the onset of laryngeal closure; there were however no differences in dyspnea intensity between groups. Conclusion: Using simultaneous measurements of respiratory mechanics and diaphragm electromyography with endoscopic video we demonstrate, for the first time, increased work of breathing and respiratory neural drive in association with the development of EILO. Future detailed investigations are now needed to understand the role of upper airway closure in causing exertional dyspnea and exercise limitation.

Original languageEnglish
JournalJournal of applied physiology (Bethesda, Md. : 1985)
Volume124
Issue number2
Pages (from-to)356-363
ISSN8750-7587
DOIs
Publication statusPublished - 1 Feb 2018

    Research areas

  • Journal Article

ID: 51980585