Increased postprandial GIP and glucagon responses, but unaltered GLP-1 response after intervention with steroid hormone, relative physical inactivity, and high-calorie diet in healthy subjects

Katrine Bagge  Hansen; Tina Vilsbøll; Jonatan I Bagger; Jens Juul Holst; Filip K Knop

doi:10.1210/jc.2010-1605

Increased postprandial GIP and glucagon responses, but unaltered GLP-1 response after intervention with steroid hormone, relative physical inactivity, and high-calorie diet in healthy subjects

Katrine Bagge Hansen, Tina Vilsbøll, Jonatan I Bagger, Jens Juul Holst, Filip K Knop

Department of Clinical Physiology and Nuclear Medicine

43 Citations (Scopus)

Abstract

Increased postprandial glucose-dependent insulinotropic polypeptide (GIP) and glucagon responses and reduced postprandial glucagon-like peptide-1 (GLP-1) responses have been observed in some patients with type 2 diabetes mellitus. The causality of these pathophysiological traits is unknown. We aimed to determine the impact of insulin resistance and reduced glucose tolerance on postprandial GIP, GLP-1, and glucagon responses in healthy subjects.

Original language	English
Journal	The Journal of clinical endocrinology and metabolism
Volume	96
Issue number	2
Pages (from-to)	447-53
Number of pages	7
DOIs	https://doi.org/10.1210/jc.2010-1605
Publication status	Published - 1 Feb 2011

Access to Document

10.1210/jc.2010-1605

Cite this

Hansen, K. B., Vilsbøll, T., Bagger, J. I., Holst, J. J., & Knop, F. K. (2011). Increased postprandial GIP and glucagon responses, but unaltered GLP-1 response after intervention with steroid hormone, relative physical inactivity, and high-calorie diet in healthy subjects. The Journal of clinical endocrinology and metabolism, 96(2), 447-53. https://doi.org/10.1210/jc.2010-1605

Increased postprandial GIP and glucagon responses, but unaltered GLP-1 response after intervention with steroid hormone, relative physical inactivity, and high-calorie diet in healthy subjects. / Hansen, Katrine Bagge ; Vilsbøll, Tina ; Bagger, Jonatan I et al.
In: The Journal of clinical endocrinology and metabolism, Vol. 96, No. 2, 01.02.2011, p. 447-53.

Research output: Contribution to journal › Journal article › Research › peer-review

Hansen, KB , Vilsbøll, T , Bagger, JI, Holst, JJ & Knop, FK 2011, 'Increased postprandial GIP and glucagon responses, but unaltered GLP-1 response after intervention with steroid hormone, relative physical inactivity, and high-calorie diet in healthy subjects', The Journal of clinical endocrinology and metabolism, vol. 96, no. 2, pp. 447-53. https://doi.org/10.1210/jc.2010-1605

@article{35a80afd70b44d9bb6eed3b25a88c3c2,

title = "Increased postprandial GIP and glucagon responses, but unaltered GLP-1 response after intervention with steroid hormone, relative physical inactivity, and high-calorie diet in healthy subjects",

abstract = "Increased postprandial glucose-dependent insulinotropic polypeptide (GIP) and glucagon responses and reduced postprandial glucagon-like peptide-1 (GLP-1) responses have been observed in some patients with type 2 diabetes mellitus. The causality of these pathophysiological traits is unknown. We aimed to determine the impact of insulin resistance and reduced glucose tolerance on postprandial GIP, GLP-1, and glucagon responses in healthy subjects.",

author = "Hansen, \{Katrine Bagge\} and Tina Vilsb{\o}ll and Bagger, \{Jonatan I\} and Holst, \{Jens Juul\} and Knop, \{Filip K\}",

year = "2011",

month = feb,

day = "1",

doi = "10.1210/jc.2010-1605",

language = "English",

volume = "96",

pages = "447--53",

journal = "The Journal of clinical endocrinology and metabolism",

issn = "1945-7197",

publisher = "Endocrine Society",

number = "2",

}

TY - JOUR

T1 - Increased postprandial GIP and glucagon responses, but unaltered GLP-1 response after intervention with steroid hormone, relative physical inactivity, and high-calorie diet in healthy subjects

AU - Hansen, Katrine Bagge

AU - Vilsbøll, Tina

AU - Bagger, Jonatan I

AU - Holst, Jens Juul

AU - Knop, Filip K

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Increased postprandial glucose-dependent insulinotropic polypeptide (GIP) and glucagon responses and reduced postprandial glucagon-like peptide-1 (GLP-1) responses have been observed in some patients with type 2 diabetes mellitus. The causality of these pathophysiological traits is unknown. We aimed to determine the impact of insulin resistance and reduced glucose tolerance on postprandial GIP, GLP-1, and glucagon responses in healthy subjects.

AB - Increased postprandial glucose-dependent insulinotropic polypeptide (GIP) and glucagon responses and reduced postprandial glucagon-like peptide-1 (GLP-1) responses have been observed in some patients with type 2 diabetes mellitus. The causality of these pathophysiological traits is unknown. We aimed to determine the impact of insulin resistance and reduced glucose tolerance on postprandial GIP, GLP-1, and glucagon responses in healthy subjects.

UR - https://www.scopus.com/pages/publications/79951717902

U2 - 10.1210/jc.2010-1605

DO - 10.1210/jc.2010-1605

M3 - Journal article

C2 - 21047927

SN - 1945-7197

VL - 96

SP - 447

EP - 453

JO - The Journal of clinical endocrinology and metabolism

JF - The Journal of clinical endocrinology and metabolism

IS - 2

ER -

Increased postprandial GIP and glucagon responses, but unaltered GLP-1 response after intervention with steroid hormone, relative physical inactivity, and high-calorie diet in healthy subjects

Abstract

Access to Document

Other files and links

Fingerprint

Cite this