Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Increased long-term risk of heart failure and other adverse cardiac outcomes in dermatomyositis and polymyositis: Insights from a nationwide cohort

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Antibody-dependent neutralizing capacity of the SARS-CoV-2 vaccine BNT162b2 with and without previous COVID-19 priming

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Increased vulnerability to Covid-19 in chronic kidney disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Response to letter regarding Tobacco smoking

    Research output: Contribution to journalLetterResearchpeer-review

  4. Contribution of remnant cholesterol to cardiovascular risk

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Preheart failure comorbidities and impact on prognosis in heart failure patients: a nationwide study

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Temporal trends in utilization of transcatheter aortic valve replacement and patient characteristics: a nationwide study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Diabetes increases the risk of bone fractures in patients on kidney replacement therapy: A DANISH national cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Pharmacoepidemiological methods for computing the duration of pharmacological prescriptions using secondary data sources

    Research output: Contribution to journalReviewResearchpeer-review

  4. Temporal variation in out-of-hospital cardiac arrest occurrence in individuals with or without diabetes

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Mounting evidence suggests that dermatomyositis/polymyositis (DM/PM) are associated with increased risk of atherosclerotic events and venous thromboembolism. However, data on the association between DM/PM and other cardiac outcomes, especially heart failure (HF), are scarce.

OBJECTIVES: To examine the long-term risk and prognosis associated with adverse cardiac outcomes in patients with DM/PM.

METHODS: Using Danish administrative registries, we included all patients ≥18 years with newly diagnosed DM/PM (1996-2018). Risks of incident outcomes were compared with non-DM/PM controls from the background population (matched 1:4 by age, sex, and comorbidity). In a secondary analysis, we compared mortality following HF diagnosis between DM/PM patients with HF and non-DM/PM patients with HF (matched 1:4 by age and sex).

RESULTS: The study population included 936 DM/PM patients (median age 58.5 years, 59.0% women) and 3744 matched non-DM/PM controls. The median follow-up was 6.9 years. Absolute 10-year risks of incident outcomes for DM/PM patients vs matched controls were as follows: HF, 6.98% (CI, 5.16-9.16%) vs 4.58% (3.79-5.47%) (P = 0.002); atrial fibrillation, 10.17% (7.94-12.71%) vs 7.07% (6.09-8.15%) (P = 0.005); the composite of ICD implantation/ventricular arrhythmias/cardiac arrest, 1.99% (1.12-3.27%) vs 0.64% (0.40-0.98%) (P = 0.02); and all-cause mortality, 35.42% (31.64-39.21%) vs 16.57% (15.10-18.10%) (P < 0.0001). DM/PM with subsequent HF was associated with higher mortality compared with HF without DM/PM (adjusted hazard ratio 1.58 [CI, 1.01-2.47]).

CONCLUSION: Patients with DM/PM had a higher associated risk of HF and other adverse cardiac outcomes compared with matched controls. Among patients developing HF, a history of DM/PM was associated with higher mortality.

Original languageEnglish
JournalJournal of Internal Medicine
Volume290
Issue number3
Pages (from-to)704-714
Number of pages11
ISSN0954-6820
DOIs
Publication statusPublished - Sep 2021

Bibliographical note

© 2021 The Association for the Publication of the Journal of Internal Medicine.

    Research areas

  • atrial fibrillation, autoimmune disease, cohort study, heart failure, inflammation

ID: 68134399