Increased long-term mortality after a high perioperative inspiratory oxygen fraction during abdominal surgery: follow-up of a randomized clinical trial

Christian S Meyhoff; Lars N Jorgensen; Jørn Wetterslev; Karl Bang Christensen; Lars S Rasmussen; PROXI Trial Group

doi:10.1213/ANE.0b013e3182652a51

Increased long-term mortality after a high perioperative inspiratory oxygen fraction during abdominal surgery: follow-up of a randomized clinical trial

Christian S Meyhoff, Lars N Jorgensen, Jørn Wetterslev, Karl Bang Christensen, Lars S Rasmussen, PROXI Trial Group

154 Citations (Scopus)

Abstract

A high perioperative inspiratory oxygen fraction (80%) has been recommended to prevent postoperative wound infections. However, the most recent and one of the largest trials, the PROXI trial, found no reduction in surgical site infection, and 30-day mortality was higher in patients given 80% oxygen. In this follow-up study of the PROXI trial we assessed the association between long-term mortality and perioperative oxygen fraction in patients undergoing abdominal surgery.

Original language	English
Journal	Anesthesia and Analgesia
Volume	115
Issue number	4
Pages (from-to)	849-54
Number of pages	6
ISSN	0003-2999
DOIs	https://doi.org/10.1213/ANE.0b013e3182652a51
Publication status	Published - 2012

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Increased long-term mortality after a high perioperative inspiratory oxygen fraction during abdominal surgery: follow-up of a randomized clinical trial. / Meyhoff, Christian S ; Jorgensen, Lars N; Wetterslev, Jørn et al.
In: Anesthesia and Analgesia, Vol. 115, No. 4, 2012, p. 849-54.

Research output: Contribution to journal › Journal article › Research › peer-review

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AU - Rasmussen, Lars S

AU - PROXI Trial Group

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Increased long-term mortality after a high perioperative inspiratory oxygen fraction during abdominal surgery: follow-up of a randomized clinical trial

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