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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Increased incidence of mental disorders in children with cataract - findings from a population-based study

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PURPOSE: To examine the incidence of mental disorders in children with cataract compared with children without cataract.

DESIGN: Nationwide cohort study based on entries in comprehensive national databases.

METHODS: The incidence of mental disorders in children born between 2000 and 2017 diagnosed with cataract before 10 years of age (n = 485) was compared with sex- and age-matched controls (n = 4358). Analyses were corrected to somatic disease in the child and parental socioeconomic status and psychiatric morbidity. The study was conducted as 2 university hospitals in Denmark managing children 6 years of age our younger with cataract.

RESULTS: The incidence of mental disorders was nearly doubled in children with cataract compared with controls (odds ratio [OR], 1.83; 95% CI, 1.28-3.63). The risk of anxiety disorders was quadrupled (OR, 4.10; 95% CI, 1.90-8.84) and the risk of developmental delay was doubled (OR, 2.66; 95% CI, 1.45-4.90). The risk of mental disorders was significantly higher in children diagnosed with cataract in the first 3 years of life compared with controls (OR, 2.36; 95% CI, 1.53-3.64), whereas those diagnosed with cataract later in childhood did not have an increased risk (OR, 1.24; 95% CI, 0.66-2.30).

CONCLUSIONS: The risk of mental disorders, in particular anxiety and neurodevelopmental delay, is markedly increased in children with cataract and even more so in those diagnosed within the first 3 years of life. Psychiatric screening instruments may be integrated in the management of these children.

Original languageEnglish
JournalAmerican Journal of Ophthalmology
Volume236
Pages (from-to)204-211
Number of pages8
ISSN0002-9394
DOIs
Publication statusPublished - Apr 2022

Bibliographical note

Copyright © 2021. Published by Elsevier Inc.

    Research areas

  • Anxiety Disorders/epidemiology, Cataract/epidemiology, Child, Cohort Studies, Denmark/epidemiology, Humans, Incidence, Mental Disorders/diagnosis, Registries

ID: 69981183