Increased concordance of severe respiratory syncytial virus infection in identical twins

Simon Francis Thomsen; Lone Graff Stensballe; Axel Skytthe; Kirsten Ohm Kyvik; Vibeke Backer; Hans Bisgaard

doi:10.1542/peds.2007-1889

Increased concordance of severe respiratory syncytial virus infection in identical twins

Simon Francis Thomsen, Lone Graff Stensballe, Axel Skytthe, Kirsten Ohm Kyvik, Vibeke Backer, Hans Bisgaard

66 Citations (Scopus)

Abstract

OBJECTIVE: We estimated differences in the severity of respiratory syncytial virus infection attributable to genetic and environmental factors.

METHODS: Record linkage data on hospitalizations attributable to respiratory syncytial virus infection were gathered on all twins (12,346 pairs) born in Denmark between 1994 and 2003. Latent-factor models of genetic and environmental effects were fitted to the observed data by using maximal likelihood methods.

RESULTS: Identical twins resembled each other significantly more than did fraternal twins for respiratory syncytial virus hospitalization (concordance rate: 0.66 vs 0.53), which suggests genetic influences on disease severity. Genetic factors accounted for 16%, family environment for 73%, and nonshared environment for 11% of the individual susceptibility to develop severe respiratory syncytial virus infection.

CONCLUSIONS: The severity of respiratory syncytial virus infection is determined partly by genetic factors. This result should stimulate the search for genetic markers of disease severity.

Original language	English
Journal	Pediatrics
Volume	121
Issue number	3
Pages (from-to)	493-6
Number of pages	4
ISSN	0031-4005
DOIs	https://doi.org/10.1542/peds.2007-1889
Publication status	Published - Mar 2008

Keywords

Age Distribution
Antigens, Viral
Child, Preschool
Confidence Intervals
Denmark
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Genetic Predisposition to Disease
Humans
Incidence
Infant
Male
Probability
Proportional Hazards Models
Registries
Respiratory Syncytial Virus Infections
Retrospective Studies
Risk Factors
Severity of Illness Index
Sex Distribution
Twins, Monozygotic

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10.1542/peds.2007-1889

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title = "Increased concordance of severe respiratory syncytial virus infection in identical twins",

abstract = "OBJECTIVE: We estimated differences in the severity of respiratory syncytial virus infection attributable to genetic and environmental factors.METHODS: Record linkage data on hospitalizations attributable to respiratory syncytial virus infection were gathered on all twins (12,346 pairs) born in Denmark between 1994 and 2003. Latent-factor models of genetic and environmental effects were fitted to the observed data by using maximal likelihood methods.RESULTS: Identical twins resembled each other significantly more than did fraternal twins for respiratory syncytial virus hospitalization (concordance rate: 0.66 vs 0.53), which suggests genetic influences on disease severity. Genetic factors accounted for 16\%, family environment for 73\%, and nonshared environment for 11\% of the individual susceptibility to develop severe respiratory syncytial virus infection.CONCLUSIONS: The severity of respiratory syncytial virus infection is determined partly by genetic factors. This result should stimulate the search for genetic markers of disease severity.",

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author = "Thomsen, \{Simon Francis\} and Stensballe, \{Lone Graff\} and Axel Skytthe and Kyvik, \{Kirsten Ohm\} and Vibeke Backer and Hans Bisgaard",

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doi = "10.1542/peds.2007-1889",

language = "English",

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T1 - Increased concordance of severe respiratory syncytial virus infection in identical twins

AU - Thomsen, Simon Francis

AU - Stensballe, Lone Graff

AU - Skytthe, Axel

AU - Kyvik, Kirsten Ohm

AU - Backer, Vibeke

AU - Bisgaard, Hans

PY - 2008/3

Y1 - 2008/3

N2 - OBJECTIVE: We estimated differences in the severity of respiratory syncytial virus infection attributable to genetic and environmental factors.METHODS: Record linkage data on hospitalizations attributable to respiratory syncytial virus infection were gathered on all twins (12,346 pairs) born in Denmark between 1994 and 2003. Latent-factor models of genetic and environmental effects were fitted to the observed data by using maximal likelihood methods.RESULTS: Identical twins resembled each other significantly more than did fraternal twins for respiratory syncytial virus hospitalization (concordance rate: 0.66 vs 0.53), which suggests genetic influences on disease severity. Genetic factors accounted for 16%, family environment for 73%, and nonshared environment for 11% of the individual susceptibility to develop severe respiratory syncytial virus infection.CONCLUSIONS: The severity of respiratory syncytial virus infection is determined partly by genetic factors. This result should stimulate the search for genetic markers of disease severity.

AB - OBJECTIVE: We estimated differences in the severity of respiratory syncytial virus infection attributable to genetic and environmental factors.METHODS: Record linkage data on hospitalizations attributable to respiratory syncytial virus infection were gathered on all twins (12,346 pairs) born in Denmark between 1994 and 2003. Latent-factor models of genetic and environmental effects were fitted to the observed data by using maximal likelihood methods.RESULTS: Identical twins resembled each other significantly more than did fraternal twins for respiratory syncytial virus hospitalization (concordance rate: 0.66 vs 0.53), which suggests genetic influences on disease severity. Genetic factors accounted for 16%, family environment for 73%, and nonshared environment for 11% of the individual susceptibility to develop severe respiratory syncytial virus infection.CONCLUSIONS: The severity of respiratory syncytial virus infection is determined partly by genetic factors. This result should stimulate the search for genetic markers of disease severity.

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KW - Follow-Up Studies

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KW - Male

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KW - Registries

KW - Respiratory Syncytial Virus Infections

KW - Retrospective Studies

KW - Risk Factors

KW - Severity of Illness Index

KW - Sex Distribution

KW - Twins, Monozygotic

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DO - 10.1542/peds.2007-1889

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SN - 0031-4005

VL - 121

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JO - Pediatrics

JF - Pediatrics

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ER -

Increased concordance of severe respiratory syncytial virus infection in identical twins

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