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Increased abundance of proteobacteria in aggressive Crohn's disease seven years after diagnosis

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  1. A prospective three-year follow-up study on the clinical significance of anti-neuronal antibodies in acute psychiatric disorders

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  2. Inhibition of epileptiform activity by neuropeptide Y in brain tissue from drug-resistant temporal lobe epilepsy patients

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  3. Body mass index in young men and risk of inflammatory bowel disease through adult life: A population-based Danish cohort study

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  4. Leukocyte telomere length is associated with elevated plasma glucose and HbA1c in young healthy men independent of birth weight

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  1. Direct and Indirect Costs of Inflammatory Bowel Disease: Ten Years of Follow Up in a Danish Population-Based Inception Cohort

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  2. Energy expenditure and loss of muscle and fat mass in patients with walled-off pancreatic necrosis: A prospective study

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  3. Plasma calprotectin is superior to serum calprotectin as a biomarker of intestinal inflammation in ulcerative Colitis

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  4. Cardiac dysfunction in cirrhosis: a 2-yr longitudinal follow-up study using advanced cardiac imaging

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Intestinal dysbiosis in inflammatory bowel disease (IBD) patients depend on disease activity. We aimed to characterize the microbiota after 7 years of follow-up in an unselected cohort of IBD patients according to disease activity and disease severity. Fifty eight Crohn's disease (CD) and 82 ulcerative colitis (UC) patients were included. Disease activity was assessed by the Harvey-Bradshaw Index for CD and Simple Clinical Colitis Activity Index for UC. Microbiota diversity was assessed by 16S rDNA MiSeq sequencing. In UC patients with active disease and in CD patients with aggressive disease the richness (number of OTUs, p = 0.018 and p = 0.013, respectively) and diversity (Shannons index, p = 0.017 and p = 0.023, respectively) were significantly decreased. In the active UC group there was a significant decrease in abundance of the phylum Firmicutes (p = 0.018). The same was found in CD patients with aggressive disease (p = 0.05) while the abundance of Proteobacteria phylum showed a significant increase (p = 0.03) in CD patients. We found a change in the microbial abundance in UC patients with active disease and in CD patients with aggressive disease. These results suggest that dysbiosis of the gut in IBD patients is not only related to current activity but also to the course of the disease.

Original languageEnglish
Article number13473
JournalScientific Reports
Volume9
ISSN2045-2322
DOIs
Publication statusPublished - 17 Sep 2019

ID: 57995976