Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Incidental and Non-incidental Papillary Thyroid Microcarcinoma in Denmark 1996-2015: A national study on incidence, outcome and thoughts on active surveillance

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Rational targeting of population groups and residential areas for colorectal cancer screening

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Answer to: "Is the National Danish Colorectal Cancer Screening Programme a success?"

    Research output: Contribution to journalJournal articleResearch

  3. Birthweight and risk of thyroid cancer and its histological types: A large cohort study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Three years of colorectal cancer screening in Denmark

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Trends in thyroid cancer: Retrospective analysis of incidence and survival in Denmark 1980-2014

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Completeness of RET testing in patients with medullary thyroid carcinoma in Denmark 1997-2013: a nationwide study

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Replication of newly proposed TNM staging system for medullary thyroid carcinoma: a nationwide study

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. The nephroprotective effect of Mannitol in head and neck cancer patients receiving Cisplatin therapy

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Therapeutic human papillomavirus vaccines in head and neck cancer: A systematic review of current clinical trials

    Research output: Contribution to journalReviewResearchpeer-review

  5. Incidence and prevalence of multiple endocrine neoplasia 2A in Denmark 1901-2014: a nationwide study

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Rasmus Reinke
  • Jes Sloth Mathiesen
  • Stine Rosenkilde Larsen
  • Christoffer Holst Hahn
  • Henrik Baymler Pedersen
  • Jens Bentzen
  • Sten Schytte
  • Christian Godballe
  • Stefano Christian Londero
  • A study from The Danish Thyroid Cancer Group – DATHYRCA (part of the DAHANCA organization)
View graph of relations

BACKGROUND: Incidental and non-incidental papillary microcarcinomas (PMC) are associated with different outcomes and treatment options may vary. The least favourable outcome is typically seen when carcinoma is suspected prior to surgery. Only a few studies have addressed the prognosis based on the way of detection for PMC, and they have been limited to retrospective single-center studies. We hypothesize that the "way of detection" may predict prognosis. The aim was to calculate the incidence and outcome of PMC based on the way of detection and to identify patients that may be suitable for active surveillance.

METHOD: This national cohort study consists of 803 patients diagnosed with PMC in Denmark from 1996 to 2015. Patients were identified from the DATHYRCA database and allocated into groups according to the way of detection leading to surgery: Incidental at surgery (n = 527), non-incidental with symptoms suspected from the index tumor (n = 134) and non-incidental with symptoms suspected from a metastasis (n = 142).

RESULTS: Age-standardized incidence rates increased from 0.35 per 100,000 per year in 1996 to 1.19 per 100,000 per year in 2015. A significant rise in incidence was found for both the incidental group and non-incidental group with symptoms suspected from a metastasis. Recurrence free survival was significantly worse for patients with suspicion of metastasis prior to surgery than patient groups without. No difference in mortality was found between groups.

CONCLUSION: PMC patients without suspicion of metastasis have the same low risk of recurrence as incidental cases and may be candidates for active surveillance.

Original languageEnglish
JournalCancer epidemiology
Volume60
Pages (from-to)46-50
Number of pages5
ISSN1877-7821
DOIs
Publication statusPublished - Jun 2019

ID: 58055794