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Incidence, risk factors and evaluation of osteoporosis in patients with inflammatory bowel disease - a Danish population-based inception cohort with 10 years of follow-up

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@article{60da893ca02649c2967fd63bfa1a13b6,
title = "Incidence, risk factors and evaluation of osteoporosis in patients with inflammatory bowel disease - a Danish population-based inception cohort with 10 years of follow-up",
abstract = "BACKGROUND: Patients with inflammatory bowel disease (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) are at risk of developing metabolic bone disease. The aims were to investigate the screening strategy, incidence and risk factors of osteoporosis in a prospective population-based inception cohort.METHOD: Between 2003-2004 all incident patients diagnosed with CD and UC in a well-defined Copenhagen area were included and followed until 2015. Data were compared with a control population (1:20). Regression models were performed with several covariates. The sensitivity of the Danish registries for osteoporosis was also assessed.RESULTS: A total of 513 patients were included (213 CD, 300 UC). Overall, 338 (66{\%}, CD: 164 [77{\%}], UC: 174 [58{\%}], p<0.001) patients received ≥500 mg corticosteroid within a year, resulting in 781 patient years at risk of osteoporosis. Of those, only 83 (10.6{\%}) patient years were followed by a Dual-energy X-ray absorptiometry scan within the same or the following 2 years.Overall, 73 (14.2{\%}) IBD patients (CD: 31 [14.6{\%}], UC: 42 [14{\%}]) and 680 (6.6{\%}, p<0.001) controls were diagnosed with osteoporosis during follow-up. The risk of osteoporosis was increased compared to the control population (OR: CD: 2.9 [CI95{\%}: 2.0-4.1], UC: 2.8 [2.1-3.9]).CONCLUSION: In this population-based inception cohort the incidence of osteoporosis was significantly higher compared to a control population. Measurement of bone mineral density is infrequent, especially in patients at high-risk of developing osteoporosis. These results demonstrate the need of further awareness of the risk of osteoporosis among IBD patients and prospective population-based studies are wanted.",
author = "Bobby Lo and Holm, {Jakob Pr{\ae}st} and Vester-Andersen, {Marianne Kajb{\ae}k} and Flemming Bendtsen and Ida Vind and Johan Burisch",
note = "Copyright {\circledC} 2020 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.",
year = "2020",
month = "2",
day = "4",
doi = "10.1093/ecco-jcc/jjaa019",
language = "English",
journal = "Journal of Crohn's and Colitis",
issn = "1873-9946",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Incidence, risk factors and evaluation of osteoporosis in patients with inflammatory bowel disease - a Danish population-based inception cohort with 10 years of follow-up

AU - Lo, Bobby

AU - Holm, Jakob Præst

AU - Vester-Andersen, Marianne Kajbæk

AU - Bendtsen, Flemming

AU - Vind, Ida

AU - Burisch, Johan

N1 - Copyright © 2020 European Crohn’s and Colitis Organisation (ECCO). Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

PY - 2020/2/4

Y1 - 2020/2/4

N2 - BACKGROUND: Patients with inflammatory bowel disease (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) are at risk of developing metabolic bone disease. The aims were to investigate the screening strategy, incidence and risk factors of osteoporosis in a prospective population-based inception cohort.METHOD: Between 2003-2004 all incident patients diagnosed with CD and UC in a well-defined Copenhagen area were included and followed until 2015. Data were compared with a control population (1:20). Regression models were performed with several covariates. The sensitivity of the Danish registries for osteoporosis was also assessed.RESULTS: A total of 513 patients were included (213 CD, 300 UC). Overall, 338 (66%, CD: 164 [77%], UC: 174 [58%], p<0.001) patients received ≥500 mg corticosteroid within a year, resulting in 781 patient years at risk of osteoporosis. Of those, only 83 (10.6%) patient years were followed by a Dual-energy X-ray absorptiometry scan within the same or the following 2 years.Overall, 73 (14.2%) IBD patients (CD: 31 [14.6%], UC: 42 [14%]) and 680 (6.6%, p<0.001) controls were diagnosed with osteoporosis during follow-up. The risk of osteoporosis was increased compared to the control population (OR: CD: 2.9 [CI95%: 2.0-4.1], UC: 2.8 [2.1-3.9]).CONCLUSION: In this population-based inception cohort the incidence of osteoporosis was significantly higher compared to a control population. Measurement of bone mineral density is infrequent, especially in patients at high-risk of developing osteoporosis. These results demonstrate the need of further awareness of the risk of osteoporosis among IBD patients and prospective population-based studies are wanted.

AB - BACKGROUND: Patients with inflammatory bowel disease (IBD) including Crohn's disease (CD) and ulcerative colitis (UC) are at risk of developing metabolic bone disease. The aims were to investigate the screening strategy, incidence and risk factors of osteoporosis in a prospective population-based inception cohort.METHOD: Between 2003-2004 all incident patients diagnosed with CD and UC in a well-defined Copenhagen area were included and followed until 2015. Data were compared with a control population (1:20). Regression models were performed with several covariates. The sensitivity of the Danish registries for osteoporosis was also assessed.RESULTS: A total of 513 patients were included (213 CD, 300 UC). Overall, 338 (66%, CD: 164 [77%], UC: 174 [58%], p<0.001) patients received ≥500 mg corticosteroid within a year, resulting in 781 patient years at risk of osteoporosis. Of those, only 83 (10.6%) patient years were followed by a Dual-energy X-ray absorptiometry scan within the same or the following 2 years.Overall, 73 (14.2%) IBD patients (CD: 31 [14.6%], UC: 42 [14%]) and 680 (6.6%, p<0.001) controls were diagnosed with osteoporosis during follow-up. The risk of osteoporosis was increased compared to the control population (OR: CD: 2.9 [CI95%: 2.0-4.1], UC: 2.8 [2.1-3.9]).CONCLUSION: In this population-based inception cohort the incidence of osteoporosis was significantly higher compared to a control population. Measurement of bone mineral density is infrequent, especially in patients at high-risk of developing osteoporosis. These results demonstrate the need of further awareness of the risk of osteoporosis among IBD patients and prospective population-based studies are wanted.

U2 - 10.1093/ecco-jcc/jjaa019

DO - 10.1093/ecco-jcc/jjaa019

M3 - Journal article

JO - Journal of Crohn's and Colitis

JF - Journal of Crohn's and Colitis

SN - 1873-9946

ER -

ID: 59245976