Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

In vivo tensor-valued diffusion MRI of focal demyelination in white and deep grey matter of rodents

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Dopamine agonist treatment increases sensitivity to gamble outcomes in the hippocampus in de novo Parkinson's disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Evaluating 2-[F-18]FDG-PET in differential diagnosis of dementia using a data-driven decision model

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Linking brain activity during sequential gambling to impulse control in Parkinson's disease

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Migraine with aura in women is not associated with structural thalamic abnormalities

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Dimethyl Fumarate Treatment in Patients With Primary Progressive Multiple Sclerosis: A Randomized, Controlled Trial

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Using MR elastography to assess portal hypertension and response to beta-blockers in patients with cirrhosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Cerebrospinal fluid and plasma distribution of anti-α-synuclein IgMs and IgGs in multiple system atrophy and Parkinson's disease

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease leading to damage of white matter (WM) and grey matter (GM). Magnetic resonance imaging (MRI) is the modality of choice to assess brain damage in MS, but there is an unmet need in MRI for achieving higher sensitivity and specificity to MS-related microstructural alterations in WM and GM.

OBJECTIVE: To explore whether tensor-valued diffusion MRI (dMRI) can yield sensitive microstructural read-outs for focal demyelination in cerebral WM and deep GM (DGM).

METHODS: Eight rats underwent L-α-Lysophosphatidylcholine (LPC) injections in the WM and striatum to introduce focal demyelination. Multimodal MRI was performed at 7 Tesla after 7 days. Tensor-valued dMRI was complemented by diffusion tensor imaging, quantitative MRI and proton magnetic resonance spectroscopy (MRS).

RESULTS: Quantitative MRI and MRS confirmed that LPC injections caused inflammatory demyelinating lesions in WM and DGM. Tensor-valued dMRI illustrated a significant decline of microscopic fractional anisotropy (µFA) in both LPC-treated WM and DGM (P < 0.005) along with a marked increase of isotropic kurtosis (MKI) in DGM (P < 0.0001).

CONCLUSION: Tensor-valued dMRI bears considerable potential for microstructural imaging in MS, suggesting a regional µFA decrease may be a sensitive indicator of MS lesions, while a regional MKI increase may be particularly sensitive in detecting DGM lesions of MS.

Original languageEnglish
Article number102675
JournalNeuroImage. Clinical
Volume30
Number of pages1
ISSN2213-1582
DOIs
Publication statusPublished - 2021

    Research areas

  • Microscopic fractional anisotropy, Isotropic kurtosis, Tensor-valued diffusion, Metabolic alterations, Deep grey matter demyelination, DTI, Rodentia, Rats, Gray Matter/diagnostic imaging, Multiple Sclerosis/diagnostic imaging, White Matter/diagnostic imaging, Diffusion Tensor Imaging, Brain/diagnostic imaging, Animals, Anisotropy, Diffusion Magnetic Resonance Imaging

ID: 66572537