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In vivo Motion Correction in Super Resolution Imaging of Rat Kidneys

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Taghavi, Iman ; Andersen, Sofie Bech ; Hoyos, Carlos Armando Villagomez ; Nielsen, Michael Bachmann ; Sorensen, Charlotte Mehlin ; Jensen, Jorgen Arendt. / In vivo Motion Correction in Super Resolution Imaging of Rat Kidneys. In: IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control. 2021 ; Vol. 68, No. 10. pp. 3082-3093.

Bibtex

@article{21a5210780a4431f97be9127ebce732e,
title = "In vivo Motion Correction in Super Resolution Imaging of Rat Kidneys",
abstract = "Super-resolution (SR) imaging has the potential of visualizing the microvasculature down to the 10- [Formula: see text] level, but motion induced by breathing, heartbeats, and muscle contractions are often significantly above this level. This article, therefore, introduces a method for estimating tissue motion and compensating for this. The processing pipeline is described and validated using Field II simulations of an artificial kidney. In vivo measurements were conducted using a modified bk5000 research scanner (BK Medical, Herlev, Denmark) with a BK 9009 linear array probe employing a pulse amplitude modulation scheme. The left kidney of ten Sprague-Dawley rats was scanned during open laparotomy. A 1:10 diluted SonoVue contrast agent (Bracco, Milan, Italy) was injected through a jugular vein catheter at 100 [Formula: see text]/min. Motion was estimated using speckle tracking and decomposed into contributions from the heartbeats, breathing, and residual motion. The estimated peak motions and their precisions were: heart: axial- [Formula: see text] and lateral- [Formula: see text], breathing: axial- [Formula: see text] and lateral- [Formula: see text], and residual: axial-30 [Formula: see text] and lateral-90 [Formula: see text]. The motion corrected microbubble tracks yielded SR images of both bubble density and blood vector velocity. The estimation was, thus, sufficiently precise to correct shifts down to the 10- [Formula: see text] capillary level. Similar results were found in the other kidney measurements with a restoration of resolution for the small vessels demonstrating that motion correction in 2-D can enhance SR imaging quality.",
keywords = "Apertures, Imaging, Kidney, Pipelines, Rats, Signal to noise ratio, Tracking",
author = "Iman Taghavi and Andersen, {Sofie Bech} and Hoyos, {Carlos Armando Villagomez} and Nielsen, {Michael Bachmann} and Sorensen, {Charlotte Mehlin} and Jensen, {Jorgen Arendt}",
year = "2021",
month = oct,
doi = "10.1109/TUFFC.2021.3086983",
language = "English",
volume = "68",
pages = "3082--3093",
journal = "I E E E Transactions on Ultrasonics, Ferroelectrics and Frequency Control",
issn = "0885-3010",
publisher = "I E E E",
number = "10",

}

RIS

TY - JOUR

T1 - In vivo Motion Correction in Super Resolution Imaging of Rat Kidneys

AU - Taghavi, Iman

AU - Andersen, Sofie Bech

AU - Hoyos, Carlos Armando Villagomez

AU - Nielsen, Michael Bachmann

AU - Sorensen, Charlotte Mehlin

AU - Jensen, Jorgen Arendt

PY - 2021/10

Y1 - 2021/10

N2 - Super-resolution (SR) imaging has the potential of visualizing the microvasculature down to the 10- [Formula: see text] level, but motion induced by breathing, heartbeats, and muscle contractions are often significantly above this level. This article, therefore, introduces a method for estimating tissue motion and compensating for this. The processing pipeline is described and validated using Field II simulations of an artificial kidney. In vivo measurements were conducted using a modified bk5000 research scanner (BK Medical, Herlev, Denmark) with a BK 9009 linear array probe employing a pulse amplitude modulation scheme. The left kidney of ten Sprague-Dawley rats was scanned during open laparotomy. A 1:10 diluted SonoVue contrast agent (Bracco, Milan, Italy) was injected through a jugular vein catheter at 100 [Formula: see text]/min. Motion was estimated using speckle tracking and decomposed into contributions from the heartbeats, breathing, and residual motion. The estimated peak motions and their precisions were: heart: axial- [Formula: see text] and lateral- [Formula: see text], breathing: axial- [Formula: see text] and lateral- [Formula: see text], and residual: axial-30 [Formula: see text] and lateral-90 [Formula: see text]. The motion corrected microbubble tracks yielded SR images of both bubble density and blood vector velocity. The estimation was, thus, sufficiently precise to correct shifts down to the 10- [Formula: see text] capillary level. Similar results were found in the other kidney measurements with a restoration of resolution for the small vessels demonstrating that motion correction in 2-D can enhance SR imaging quality.

AB - Super-resolution (SR) imaging has the potential of visualizing the microvasculature down to the 10- [Formula: see text] level, but motion induced by breathing, heartbeats, and muscle contractions are often significantly above this level. This article, therefore, introduces a method for estimating tissue motion and compensating for this. The processing pipeline is described and validated using Field II simulations of an artificial kidney. In vivo measurements were conducted using a modified bk5000 research scanner (BK Medical, Herlev, Denmark) with a BK 9009 linear array probe employing a pulse amplitude modulation scheme. The left kidney of ten Sprague-Dawley rats was scanned during open laparotomy. A 1:10 diluted SonoVue contrast agent (Bracco, Milan, Italy) was injected through a jugular vein catheter at 100 [Formula: see text]/min. Motion was estimated using speckle tracking and decomposed into contributions from the heartbeats, breathing, and residual motion. The estimated peak motions and their precisions were: heart: axial- [Formula: see text] and lateral- [Formula: see text], breathing: axial- [Formula: see text] and lateral- [Formula: see text], and residual: axial-30 [Formula: see text] and lateral-90 [Formula: see text]. The motion corrected microbubble tracks yielded SR images of both bubble density and blood vector velocity. The estimation was, thus, sufficiently precise to correct shifts down to the 10- [Formula: see text] capillary level. Similar results were found in the other kidney measurements with a restoration of resolution for the small vessels demonstrating that motion correction in 2-D can enhance SR imaging quality.

KW - Apertures

KW - Imaging

KW - Kidney

KW - Pipelines

KW - Rats

KW - Signal to noise ratio

KW - Tracking

UR - http://www.scopus.com/inward/record.url?scp=85111009912&partnerID=8YFLogxK

U2 - 10.1109/TUFFC.2021.3086983

DO - 10.1109/TUFFC.2021.3086983

M3 - Journal article

C2 - 34097608

VL - 68

SP - 3082

EP - 3093

JO - I E E E Transactions on Ultrasonics, Ferroelectrics and Frequency Control

JF - I E E E Transactions on Ultrasonics, Ferroelectrics and Frequency Control

SN - 0885-3010

IS - 10

ER -

ID: 66792057