In vivo imaging of cerebral serotonin transporter and serotonin(2A) receptor binding in 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") and hallucinogen users

David Erritzoe; Vibe Frøkjær; Klaus K Holst; Maria Christoffersen; Sys Stybe Johansen; Claus Svarer; Jacob Madsen; Peter M Rasmussen; Thomas Ramsøy; Terry L Jernigan; Gitte M Knudsen

doi:10.1001/archgenpsychiatry.2011.56

In vivo imaging of cerebral serotonin transporter and serotonin(2A) receptor binding in 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") and hallucinogen users

David Erritzoe, Vibe Frøkjær, Klaus K Holst, Maria Christoffersen, Sys Stybe Johansen, Claus Svarer, Jacob Madsen, Peter M Rasmussen, Thomas Ramsøy, Terry L Jernigan, Gitte M Knudsen

78 Citations (Scopus)

Abstract

Both hallucinogens and 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") have direct agonistic effects on postsynaptic serotonin(2A) receptors, the key site for hallucinogenic actions. In addition, MDMA is a potent releaser and reuptake inhibitor of presynaptic serotonin.

Original language	English
Journal	Archives of General Psychiatry
Volume	68
Issue number	6
Pages (from-to)	562-76
Number of pages	15
ISSN	0003-990X
DOIs	https://doi.org/10.1001/archgenpsychiatry.2011.56
Publication status	Published - 2011

Keywords

Adult
Amphetamine-Related Disorders
Aniline Compounds
Brain
Case-Control Studies
Cross-Sectional Studies
Female
Fluorine Radioisotopes
Hallucinogens
Humans
Ketanserin
Male
N-Methyl-3,4-methylenedioxyamphetamine
Positron-Emission Tomography
Protein Binding
Radioligand Assay
Receptor, Serotonin, 5-HT2A
Serotonin Plasma Membrane Transport Proteins
Sulfides

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10.1001/archgenpsychiatry.2011.56

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Erritzoe, D., Frøkjær, V., Holst, K. K., Christoffersen, M., Johansen, S. S., Svarer, C., Madsen, J., Rasmussen, P. M., Ramsøy, T., Jernigan, T. L., & Knudsen, G. M. (2011). In vivo imaging of cerebral serotonin transporter and serotonin(2A) receptor binding in 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") and hallucinogen users. Archives of General Psychiatry, 68(6), 562-76. https://doi.org/10.1001/archgenpsychiatry.2011.56

In vivo imaging of cerebral serotonin transporter and serotonin(2A) receptor binding in 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") and hallucinogen users. / Erritzoe, David; Frøkjær, Vibe; Holst, Klaus K et al.
In: Archives of General Psychiatry, Vol. 68, No. 6, 2011, p. 562-76.

Research output: Contribution to journal › Journal article › Research › peer-review

Erritzoe, D, Frøkjær, V, Holst, KK, Christoffersen, M, Johansen, SS, Svarer, C , Madsen, J, Rasmussen, PM, Ramsøy, T, Jernigan, TL & Knudsen, GM 2011, 'In vivo imaging of cerebral serotonin transporter and serotonin(2A) receptor binding in 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") and hallucinogen users', Archives of General Psychiatry, vol. 68, no. 6, pp. 562-76. https://doi.org/10.1001/archgenpsychiatry.2011.56

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In vivo imaging of cerebral serotonin transporter and serotonin(2A) receptor binding in 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") and hallucinogen users

Abstract

Keywords

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