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The Capital Region of Denmark - a part of Copenhagen University Hospital
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In vivo 31P magnetic resonance spectroscopy and 1H magnetic resonance imaging of human bladder carcinoma on nude mice: effects of tumour growth and treatment with cis-dichloro-diamine platinum.

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  1. Active and Passive Immunization Against Staphylococcus aureus Periprosthetic Osteomyelitis in Rats

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  2. Specific Antibodies to Staphylococcus aureus Biofilm Are Present in Serum from Pigs with Osteomyelitis

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  3. Effect of Melatonin on Human Nighttime Endotoxaemia: Randomized, Double-blinded, Cross-over Study

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  4. Melatonin Does Not Affect Oxidative/Inflammatory Biomarkers in a Closed-Chest Porcine Model of Acute Myocardial Infarction

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  1. Low incidence of non-alcoholic steatohepatitis in a Danish liver unit

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  2. Chronic recurrent multifocal osteomyelitis demonstrated by Tc-99m methylene diphosphonate bone scan.

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  3. Epstein-Barr-virus-associeret lymfom hos en patient med colitis ulcerosa i behandling med azathioprin

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  4. Cord blood inflammatory markers, foetal vasculitis and cerebral MRI abnormalities in preterm infants.

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In vivo 31P NMR spectroscopy and 1H NMR imaging were used to examine the bladder T24B carcinoma in nude mice during untreated growth and in response to chemotherapy by Cis-dichloro-diammine-platinum (CDDP) at a dose of 8 mg/kg i.p. Untreated growth was associated with an increase of inorganic phosphate and phosphomonoesters and a decrease of phosphocreatine. Fast growing tumours and early stage of regrowth after treatment presented a higher phosphocreatine/beta NTP ratio. Following CDDP treatment, 31P metabolite ratios and pH were significantly altered compared with age-matched controls, as early as 6 hours after treatment. Although necrotic area was clearly visible in MRI, no treatment effect could be detected on the images of treated tumours.
Original languageEnglish
JournalIn Vivo
Volume6
Issue number6
Pages (from-to)611-616
Number of pages6
ISSN0258-851X
Publication statusPublished - 1992

    Research areas

  • Animals, Carcinoma, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Mice, Mice, Nude, Neoplasm Transplantation, Organoplatinum Compounds, Phosphorus Radioisotopes, Transplantation, Heterologous, Urinary Bladder Neoplasms

ID: 32509486