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The Capital Region of Denmark - a part of Copenhagen University Hospital
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In vitro tendon tissue development from human fibroblasts demonstrates collagen fibril diameter growth associated with a rise in mechanical strength

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  1. Maintenance of muscle strength following a one-year resistance training program in older adults

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  2. The influence of prolonged strength training upon muscle and fat in healthy and chronically diseased older adults

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  3. Associations between shoulder symptoms and concomitant pathology in patients with traumatic supraspinatus tears

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  4. The effect of 4 months exercise training on systemic biomarkers of cartilage and bone turnover in hip osteoarthritis patients

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  5. Early development of tendinopathy in humans: Sequence of pathological changes in structure and tissue turnover signaling

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Collagen-rich tendons and ligaments are important for joint stability and force transmission, but the capacity to form new tendon is poorly understood. In the present study, we investigated mechanical strength, fibril size, and structure during development of tendon-like tissue from adult human tenocytes (termed tendon constructs) in vitro over 5 weeks in 3D tissue culture.
Original languageEnglish
JournalDevelopmental dynamics : an official publication of the American Association of Anatomists
Volume242
Issue number1
Pages (from-to)2-8
Number of pages7
DOIs
Publication statusPublished - Jan 2013

    Research areas

  • Adult, Biomechanical Phenomena, Fibrillar Collagens, Fibroblasts, Humans, Microscopy, Electron, Morphogenesis, Tendons, Tissue Culture Techniques, Tissue Engineering

ID: 42221329