In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia

Gudmar Lönnerholm; Ingrid Thörn; Christer Sundström; Britt-Marie Frost; Trond Flaegstad; Mats Heyman; Olafur Gisli Jonsson; Arja Harila-Saari; Hans O Madsen; Anna Porwit; Kjeld Schmiegelow; Stefan Söderhäll; Finn Wesenberg; Kim Vettenranta; Rolf Larsson; Erik Forestier

doi:10.1016/j.leukres.2010.09.001

In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia

Gudmar Lönnerholm, Ingrid Thörn, Christer Sundström, Britt-Marie Frost, Trond Flaegstad, Mats Heyman, Olafur Gisli Jonsson, Arja Harila-Saari, Hans O Madsen, Anna Porwit, Kjeld Schmiegelow, Stefan Söderhäll, Finn Wesenberg, Kim Vettenranta, Rolf Larsson, Erik Forestier

8 Citations (Scopus)

Abstract

Leukemic cells from 230 children with newly diagnosed B-cell precursor ALL were tested for in vitro drug resistance to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. During follow-up, 24 relapses occurred in the 159 children with MRD

Original language	English
Journal	Leukemia Research
Volume	35
Issue number	4
Pages (from-to)	472-8
Number of pages	7
ISSN	0261-474X
DOIs	https://doi.org/10.1016/j.leukres.2010.09.001
Publication status	Published - 2011

Keywords

Adolescent
Antineoplastic Agents
Antineoplastic Combined Chemotherapy Protocols
Bone Marrow Cells
Child
Child, Preschool
Chromosome Aberrations
Doxorubicin
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Female
Follow-Up Studies
Humans
Infant
Male
Neoplasm, Residual
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Prednisolone
Prognosis
Risk Factors
Vincristine

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10.1016/j.leukres.2010.09.001

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Lönnerholm, G., Thörn, I., Sundström, C., Frost, B.-M., Flaegstad, T., Heyman, M., Jonsson, O. G., Harila-Saari, A., Madsen, H. O., Porwit, A., Schmiegelow, K., Söderhäll, S., Wesenberg, F., Vettenranta, K., Larsson, R., & Forestier, E. (2011). In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia. Leukemia Research, 35(4), 472-8. https://doi.org/10.1016/j.leukres.2010.09.001

Lönnerholm, G, Thörn, I, Sundström, C, Frost, B-M, Flaegstad, T, Heyman, M, Jonsson, OG, Harila-Saari, A, Madsen, HO, Porwit, A, Schmiegelow, K, Söderhäll, S, Wesenberg, F, Vettenranta, K, Larsson, R & Forestier, E 2011, 'In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia', Leukemia Research, vol. 35, no. 4, pp. 472-8. https://doi.org/10.1016/j.leukres.2010.09.001

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title = "In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia",

abstract = "Leukemic cells from 230 children with newly diagnosed B-cell precursor ALL were tested for in vitro drug resistance to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. During follow-up, 24 relapses occurred in the 159 children with MRD ",

keywords = "Adolescent, Antineoplastic Agents, Antineoplastic Combined Chemotherapy Protocols, Bone Marrow Cells, Child, Child, Preschool, Chromosome Aberrations, Doxorubicin, Drug Resistance, Multiple, Drug Resistance, Neoplasm, Female, Follow-Up Studies, Humans, Infant, Male, Neoplasm, Residual, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prednisolone, Prognosis, Risk Factors, Vincristine",

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doi = "10.1016/j.leukres.2010.09.001",

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T1 - In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia

AU - Lönnerholm, Gudmar

AU - Thörn, Ingrid

AU - Sundström, Christer

AU - Frost, Britt-Marie

AU - Flaegstad, Trond

AU - Heyman, Mats

AU - Jonsson, Olafur Gisli

AU - Harila-Saari, Arja

AU - Madsen, Hans O

AU - Porwit, Anna

AU - Schmiegelow, Kjeld

AU - Söderhäll, Stefan

AU - Wesenberg, Finn

AU - Vettenranta, Kim

AU - Larsson, Rolf

AU - Forestier, Erik

PY - 2011

Y1 - 2011

N2 - Leukemic cells from 230 children with newly diagnosed B-cell precursor ALL were tested for in vitro drug resistance to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. During follow-up, 24 relapses occurred in the 159 children with MRD

AB - Leukemic cells from 230 children with newly diagnosed B-cell precursor ALL were tested for in vitro drug resistance to a panel of anti-cancer drugs. Minimal residual disease (MRD) was measured by RQ-PCR. During follow-up, 24 relapses occurred in the 159 children with MRD

KW - Adolescent

KW - Antineoplastic Agents

KW - Antineoplastic Combined Chemotherapy Protocols

KW - Bone Marrow Cells

KW - Child

KW - Child, Preschool

KW - Chromosome Aberrations

KW - Doxorubicin

KW - Drug Resistance, Multiple

KW - Drug Resistance, Neoplasm

KW - Female

KW - Follow-Up Studies

KW - Humans

KW - Infant

KW - Male

KW - Neoplasm, Residual

KW - Precursor Cell Lymphoblastic Leukemia-Lymphoma

KW - Prednisolone

KW - Prognosis

KW - Risk Factors

KW - Vincristine

UR - https://www.scopus.com/pages/publications/79952362834

U2 - 10.1016/j.leukres.2010.09.001

DO - 10.1016/j.leukres.2010.09.001

M3 - Journal article

C2 - 20961616

SN - 0261-474X

VL - 35

SP - 472

EP - 478

JO - Leukemia Research

JF - Leukemia Research

IS - 4

ER -

In vitro cellular drug resistance adds prognostic information to other known risk-factors in childhood acute lymphoblastic leukemia

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Keywords

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