In humans IL-6 is released from the brain during and after exercise and paralleled by enhanced IL-6 mRNA expression in the hippocampus of mice

P Rasmussen; J-C Vedel; J Olesen; Helle Adser; M V Pedersen; E Hart; N H Secher; H Pilegaard

doi:10.1111/j.1748-1716.2010.02223.x

In humans IL-6 is released from the brain during and after exercise and paralleled by enhanced IL-6 mRNA expression in the hippocampus of mice

P Rasmussen, J-C Vedel, J Olesen, Helle Adser, M V Pedersen, E Hart, N H Secher, H Pilegaard

34 Citations (Scopus)

Abstract

Aim: Plasma interleukin-6 (IL-6) increases during exercise by release from active muscles and during prolonged exercise also from the brain. The IL-6 release from muscles continues into recovery and we tested whether the brain also releases IL-6 in recovery from prolonged exercise in humans. Additionally, it was evaluated in mice whether brain release of IL-6 reflected enhanced IL-6 mRNA expression in the brain as modulated by brain glycogen levels. Methods: Nine healthy male subjects completed 4 h of ergometer rowing while the arterio-jugular venous difference (a-v diff) for IL-6 was determined. The IL-6 mRNA and the glycogen content were determined in mouse hippocampus, cerebellum and cortex before and after 2 h treadmill running (N = 8). Results: At rest, the IL-6 a-v diff was negligible but decreased to -2.2 ± 1.9 pg ml(-1) at the end of exercise and remained low (-2.1 ± 2.1 pg ml(-1) ) 1 h into the recovery (P

Original language	English
Journal	Acta physiologica (Oxford, England)
Volume	201
Issue number	4
Pages (from-to)	475-82
Number of pages	8
ISSN	1748-1708
DOIs	https://doi.org/10.1111/j.1748-1716.2010.02223.x
Publication status	Published - 1 Apr 2011

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@article{11ad6dff4e1941468dd765109e32ef71,

title = "In humans IL-6 is released from the brain during and after exercise and paralleled by enhanced IL-6 mRNA expression in the hippocampus of mice",

abstract = "Aim: Plasma interleukin-6 (IL-6) increases during exercise by release from active muscles and during prolonged exercise also from the brain. The IL-6 release from muscles continues into recovery and we tested whether the brain also releases IL-6 in recovery from prolonged exercise in humans. Additionally, it was evaluated in mice whether brain release of IL-6 reflected enhanced IL-6 mRNA expression in the brain as modulated by brain glycogen levels. Methods: Nine healthy male subjects completed 4 h of ergometer rowing while the arterio-jugular venous difference (a-v diff) for IL-6 was determined. The IL-6 mRNA and the glycogen content were determined in mouse hippocampus, cerebellum and cortex before and after 2 h treadmill running (N = 8). Results: At rest, the IL-6 a-v diff was negligible but decreased to -2.2 ± 1.9 pg ml(-1) at the end of exercise and remained low (-2.1 ± 2.1 pg ml(-1) ) 1 h into the recovery (P ",

author = "P Rasmussen and J-C Vedel and J Olesen and Helle Adser and Pedersen, {M V} and E Hart and Secher, {N H} and H Pilegaard",

note = "{\textcopyright} 2010 The Authors. Acta Physiologica {\textcopyright} 2010 Scandinavian Physiological Society.",

year = "2011",

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day = "1",

doi = "10.1111/j.1748-1716.2010.02223.x",

language = "English",

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TY - JOUR

T1 - In humans IL-6 is released from the brain during and after exercise and paralleled by enhanced IL-6 mRNA expression in the hippocampus of mice

AU - Rasmussen, P

AU - Vedel, J-C

AU - Olesen, J

AU - Adser, Helle

AU - Pedersen, M V

AU - Hart, E

AU - Secher, N H

AU - Pilegaard, H

PY - 2011/4/1

Y1 - 2011/4/1

N2 - Aim: Plasma interleukin-6 (IL-6) increases during exercise by release from active muscles and during prolonged exercise also from the brain. The IL-6 release from muscles continues into recovery and we tested whether the brain also releases IL-6 in recovery from prolonged exercise in humans. Additionally, it was evaluated in mice whether brain release of IL-6 reflected enhanced IL-6 mRNA expression in the brain as modulated by brain glycogen levels. Methods: Nine healthy male subjects completed 4 h of ergometer rowing while the arterio-jugular venous difference (a-v diff) for IL-6 was determined. The IL-6 mRNA and the glycogen content were determined in mouse hippocampus, cerebellum and cortex before and after 2 h treadmill running (N = 8). Results: At rest, the IL-6 a-v diff was negligible but decreased to -2.2 ± 1.9 pg ml(-1) at the end of exercise and remained low (-2.1 ± 2.1 pg ml(-1) ) 1 h into the recovery (P

AB - Aim: Plasma interleukin-6 (IL-6) increases during exercise by release from active muscles and during prolonged exercise also from the brain. The IL-6 release from muscles continues into recovery and we tested whether the brain also releases IL-6 in recovery from prolonged exercise in humans. Additionally, it was evaluated in mice whether brain release of IL-6 reflected enhanced IL-6 mRNA expression in the brain as modulated by brain glycogen levels. Methods: Nine healthy male subjects completed 4 h of ergometer rowing while the arterio-jugular venous difference (a-v diff) for IL-6 was determined. The IL-6 mRNA and the glycogen content were determined in mouse hippocampus, cerebellum and cortex before and after 2 h treadmill running (N = 8). Results: At rest, the IL-6 a-v diff was negligible but decreased to -2.2 ± 1.9 pg ml(-1) at the end of exercise and remained low (-2.1 ± 2.1 pg ml(-1) ) 1 h into the recovery (P

U2 - 10.1111/j.1748-1716.2010.02223.x

DO - 10.1111/j.1748-1716.2010.02223.x

M3 - Journal article

C2 - 21083649

SN - 1748-1708

VL - 201

SP - 475

EP - 482

JO - Acta physiologica (Oxford, England)

JF - Acta physiologica (Oxford, England)

IS - 4

ER -

In humans IL-6 is released from the brain during and after exercise and paralleled by enhanced IL-6 mRNA expression in the hippocampus of mice

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