In cirrhotic patients reduced muscle strength is unrelated to muscle capacity for ATP turnover suggesting a central limitation

C M B Gam; Henning M Bay Nielsen; N H Secher; F S Larsen; Peter Ott; Bjørn Quistorff

doi:10.1111/j.1475-097X.2010.00998.x

In cirrhotic patients reduced muscle strength is unrelated to muscle capacity for ATP turnover suggesting a central limitation

C M B Gam, Henning M Bay Nielsen, N H Secher, F S Larsen, Peter Ott, Bjørn Quistorff

3 Citations (Scopus)

Abstract

Background and aims: We investigated whether in patients with liver cirrhosis reduced muscle strength is related to dysfunction of muscle mitochondria. Methods: The mitochondrial respiratory capacity of the tibial anterior muscle was evaluated in seven patients and eight healthy control subjects by (31) P nuclear magnetic resonance spectroscopy ((31) PMRS) to express ATP turnover in vivo and by respirometry of permeabilized fibres from the same muscle to express the in vitro capacity for oxygen consumption. Results: Maximal voluntary contraction force for plantar extension was low in the patients (46% of the control value; P

Original language	English
Journal	Clinical Physiology and Functional Imaging
Volume	31
Issue number	3
Pages (from-to)	169-74
Number of pages	6
ISSN	1475-0961
DOIs	https://doi.org/10.1111/j.1475-097X.2010.00998.x
Publication status	Published - 1 May 2011

Access to Document

10.1111/j.1475-097X.2010.00998.x

Cite this

@article{307d3feb755644b886c36a893c26be2a,

title = "In cirrhotic patients reduced muscle strength is unrelated to muscle capacity for ATP turnover suggesting a central limitation",

abstract = "Background and aims: We investigated whether in patients with liver cirrhosis reduced muscle strength is related to dysfunction of muscle mitochondria. Methods: The mitochondrial respiratory capacity of the tibial anterior muscle was evaluated in seven patients and eight healthy control subjects by (31) P nuclear magnetic resonance spectroscopy ((31) PMRS) to express ATP turnover in vivo and by respirometry of permeabilized fibres from the same muscle to express the in vitro capacity for oxygen consumption. Results: Maximal voluntary contraction force for plantar extension was low in the patients (46% of the control value; P",

author = "Gam, {C M B} and Nielsen, {Henning M Bay} and Secher, {N H} and Larsen, {F S} and Peter Ott and Bj{\o}rn Quistorff",

note = "{\textcopyright} 2010 The Authors. Clinical Physiology and Functional Imaging {\textcopyright} 2010 Scandinavian Society of Clinical Physiology and Nuclear Medicine.",

year = "2011",

month = may,

day = "1",

doi = "10.1111/j.1475-097X.2010.00998.x",

language = "English",

volume = "31",

pages = "169--74",

journal = "Clinical Physiology and Functional Imaging",

issn = "1475-0961",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "3",

}

TY - JOUR

T1 - In cirrhotic patients reduced muscle strength is unrelated to muscle capacity for ATP turnover suggesting a central limitation

AU - Gam, C M B

AU - Nielsen, Henning M Bay

AU - Secher, N H

AU - Larsen, F S

AU - Ott, Peter

AU - Quistorff, Bjørn

PY - 2011/5/1

Y1 - 2011/5/1

N2 - Background and aims: We investigated whether in patients with liver cirrhosis reduced muscle strength is related to dysfunction of muscle mitochondria. Methods: The mitochondrial respiratory capacity of the tibial anterior muscle was evaluated in seven patients and eight healthy control subjects by (31) P nuclear magnetic resonance spectroscopy ((31) PMRS) to express ATP turnover in vivo and by respirometry of permeabilized fibres from the same muscle to express the in vitro capacity for oxygen consumption. Results: Maximal voluntary contraction force for plantar extension was low in the patients (46% of the control value; P

AB - Background and aims: We investigated whether in patients with liver cirrhosis reduced muscle strength is related to dysfunction of muscle mitochondria. Methods: The mitochondrial respiratory capacity of the tibial anterior muscle was evaluated in seven patients and eight healthy control subjects by (31) P nuclear magnetic resonance spectroscopy ((31) PMRS) to express ATP turnover in vivo and by respirometry of permeabilized fibres from the same muscle to express the in vitro capacity for oxygen consumption. Results: Maximal voluntary contraction force for plantar extension was low in the patients (46% of the control value; P

U2 - 10.1111/j.1475-097X.2010.00998.x

DO - 10.1111/j.1475-097X.2010.00998.x

M3 - Journal article

C2 - 21143366

SN - 1475-0961

VL - 31

SP - 169

EP - 174

JO - Clinical Physiology and Functional Imaging

JF - Clinical Physiology and Functional Imaging

IS - 3

ER -

In cirrhotic patients reduced muscle strength is unrelated to muscle capacity for ATP turnover suggesting a central limitation

Abstract

Access to Document

Fingerprint

Cite this