Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Improving antibiotic treatment of bacterial biofilm by hyperbaric oxygen therapy: Not just hot air

Research output: Contribution to journalReviewpeer-review

  1. Antibiotic susceptibility of cystic fibrosis lung microbiome members in a multispecies biofilm

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Genetic determinants of Pseudomonas aeruginosa fitness during biofilm growth

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Minimum information guideline for spectrofotometric and fluorometric methods to assess biofilm formation in microplates

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Into the well - A close look at the complex structures of a microtiter biofilm and the crystal violet assay

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Nonalcoholic Fatty Liver Disease and Cardiovascular Disease: Overlapping Mechanisms

    Research output: Contribution to journalReviewpeer-review

  2. APMIS pandemic editorial

    Research output: Contribution to journalEditorialpeer-review

  3. Pandemics: past, present, future: That is like choosing between cholera and plague

    Research output: Contribution to journalReviewpeer-review

  4. MR-vejledt laserablation til behandling af hjernetumorer og epilepsi

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Bacteria and fungi show substantial increased recalcitrance when growing as infectious biofilms. Chronic infections caused by biofilm growing microorganisms is considered a major problem of modern medicine. New strategies are needed to improve antibiotic treatment of biofilms. We have improved antibiotic treatment of bacterial biofilms by reviving the dormant bacteria and thereby make them susceptible to antibiotics by means of reoxygenation. Here we review the rationale for associating lack of oxygen with low susceptibility in infectious biofilm, and how hyperbaric oxygen therapy may result in reoxygenation leading to enhanced bactericidal activity of antibiotics. We address issues of feasibility and potential adverse effects regarding patient safety and development of resistance. Finally, we propose means for supplying reoxygenation to antibiotic treatment of infectious biofilm with the potential to benefit large groups of patients.

Original languageEnglish
JournalBiofilm
Volume1
Pages (from-to)100008
ISSN2590-2075
DOIs
Publication statusPublished - Dec 2020

ID: 62067810