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Improvement in indices of cellular protection after psychological treatment for social anxiety disorder

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Månsson, KNT, Lindqvist, D, Yang, LL, Svanborg, C, Isung, J, Nilsonne, G, Bergman-Nordgren, L, El Alaoui, S, Hedman-Lagerlöf, E, Kraepelien, M, Högström, J, Andersson, G, Boraxbekk, C-J, Fischer, H, Lavebratt, C, Wolkowitz, OM & Furmark, T 2019, 'Improvement in indices of cellular protection after psychological treatment for social anxiety disorder' Translational psychiatry, vol. 9, 340, pp. 1-10. https://doi.org/10.1038/s41398-019-0668-2

APA

Månsson, K. N. T., Lindqvist, D., Yang, L. L., Svanborg, C., Isung, J., Nilsonne, G., ... Furmark, T. (2019). Improvement in indices of cellular protection after psychological treatment for social anxiety disorder. Translational psychiatry, 9, 1-10. [340]. https://doi.org/10.1038/s41398-019-0668-2

CBE

Månsson KNT, Lindqvist D, Yang LL, Svanborg C, Isung J, Nilsonne G, Bergman-Nordgren L, El Alaoui S, Hedman-Lagerlöf E, Kraepelien M, Högström J, Andersson G, Boraxbekk C-J, Fischer H, Lavebratt C, Wolkowitz OM, Furmark T. 2019. Improvement in indices of cellular protection after psychological treatment for social anxiety disorder. Translational psychiatry. 9:1-10. https://doi.org/10.1038/s41398-019-0668-2

MLA

Vancouver

Author

Månsson, Kristoffer N T ; Lindqvist, Daniel ; Yang, Liu L ; Svanborg, Cecilia ; Isung, Josef ; Nilsonne, Gustav ; Bergman-Nordgren, Lise ; El Alaoui, Samir ; Hedman-Lagerlöf, Erik ; Kraepelien, Martin ; Högström, Jens ; Andersson, Gerhard ; Boraxbekk, Carl-Johan ; Fischer, Håkan ; Lavebratt, Catharina ; Wolkowitz, Owen M ; Furmark, Tomas. / Improvement in indices of cellular protection after psychological treatment for social anxiety disorder. In: Translational psychiatry. 2019 ; Vol. 9. pp. 1-10.

Bibtex

@article{29ead4cf2d3c4b9098aba033c5e391c3,
title = "Improvement in indices of cellular protection after psychological treatment for social anxiety disorder",
abstract = "Telomere attrition is a hallmark of cellular aging and shorter telomeres have been reported in mood and anxiety disorders. Telomere shortening is counteracted by the enzyme telomerase and cellular protection is also provided by the antioxidant enzyme glutathione peroxidase (GPx). Here, telomerase, GPx, and telomeres were investigated in 46 social anxiety disorder (SAD) patients in a within-subject design with repeated measures before and after cognitive behavioral therapy. Treatment outcome was assessed by the Liebowitz Social Anxiety Scale (self-report), administered three times before treatment to control for time and regression artifacts, and posttreatment. Venipunctures were performed twice before treatment, separated by 9 weeks, and once posttreatment. Telomerase activity and telomere length were measured in peripheral blood mononuclear cells and GPx activity in plasma. All patients contributed with complete data. Results showed that social anxiety symptom severity was significantly reduced from pretreatment to posttreatment (Cohen's d = 1.46). There were no significant alterations in telomeres or cellular protection markers before treatment onset. Telomere length and telomerase activity did not change significantly after treatment, but an increase in telomerase over treatment was associated with reduced social anxiety. Also, lower pretreatment telomerase activity predicted subsequent symptom improvement. GPx activity increased significantly during treatment, and increases were significantly associated with symptom improvement. The relationships between symptom improvement and putative protective enzymes remained significant also after controlling for body mass index, sex, duration of SAD, smoking, concurrent psychotropic medication, and the proportion of lymphocytes to monocytes. Thus, indices of cellular protection may be involved in the therapeutic mechanisms of psychological treatment for anxiety.",
author = "M{\aa}nsson, {Kristoffer N T} and Daniel Lindqvist and Yang, {Liu L} and Cecilia Svanborg and Josef Isung and Gustav Nilsonne and Lise Bergman-Nordgren and {El Alaoui}, Samir and Erik Hedman-Lagerl{\"o}f and Martin Kraepelien and Jens H{\"o}gstr{\"o}m and Gerhard Andersson and Carl-Johan Boraxbekk and H{\aa}kan Fischer and Catharina Lavebratt and Wolkowitz, {Owen M} and Tomas Furmark",
year = "2019",
month = "12",
day = "19",
doi = "10.1038/s41398-019-0668-2",
language = "English",
volume = "9",
pages = "1--10",
journal = "Translational Psychiatry",
issn = "2158-3188",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Improvement in indices of cellular protection after psychological treatment for social anxiety disorder

AU - Månsson, Kristoffer N T

AU - Lindqvist, Daniel

AU - Yang, Liu L

AU - Svanborg, Cecilia

AU - Isung, Josef

AU - Nilsonne, Gustav

AU - Bergman-Nordgren, Lise

AU - El Alaoui, Samir

AU - Hedman-Lagerlöf, Erik

AU - Kraepelien, Martin

AU - Högström, Jens

AU - Andersson, Gerhard

AU - Boraxbekk, Carl-Johan

AU - Fischer, Håkan

AU - Lavebratt, Catharina

AU - Wolkowitz, Owen M

AU - Furmark, Tomas

PY - 2019/12/19

Y1 - 2019/12/19

N2 - Telomere attrition is a hallmark of cellular aging and shorter telomeres have been reported in mood and anxiety disorders. Telomere shortening is counteracted by the enzyme telomerase and cellular protection is also provided by the antioxidant enzyme glutathione peroxidase (GPx). Here, telomerase, GPx, and telomeres were investigated in 46 social anxiety disorder (SAD) patients in a within-subject design with repeated measures before and after cognitive behavioral therapy. Treatment outcome was assessed by the Liebowitz Social Anxiety Scale (self-report), administered three times before treatment to control for time and regression artifacts, and posttreatment. Venipunctures were performed twice before treatment, separated by 9 weeks, and once posttreatment. Telomerase activity and telomere length were measured in peripheral blood mononuclear cells and GPx activity in plasma. All patients contributed with complete data. Results showed that social anxiety symptom severity was significantly reduced from pretreatment to posttreatment (Cohen's d = 1.46). There were no significant alterations in telomeres or cellular protection markers before treatment onset. Telomere length and telomerase activity did not change significantly after treatment, but an increase in telomerase over treatment was associated with reduced social anxiety. Also, lower pretreatment telomerase activity predicted subsequent symptom improvement. GPx activity increased significantly during treatment, and increases were significantly associated with symptom improvement. The relationships between symptom improvement and putative protective enzymes remained significant also after controlling for body mass index, sex, duration of SAD, smoking, concurrent psychotropic medication, and the proportion of lymphocytes to monocytes. Thus, indices of cellular protection may be involved in the therapeutic mechanisms of psychological treatment for anxiety.

AB - Telomere attrition is a hallmark of cellular aging and shorter telomeres have been reported in mood and anxiety disorders. Telomere shortening is counteracted by the enzyme telomerase and cellular protection is also provided by the antioxidant enzyme glutathione peroxidase (GPx). Here, telomerase, GPx, and telomeres were investigated in 46 social anxiety disorder (SAD) patients in a within-subject design with repeated measures before and after cognitive behavioral therapy. Treatment outcome was assessed by the Liebowitz Social Anxiety Scale (self-report), administered three times before treatment to control for time and regression artifacts, and posttreatment. Venipunctures were performed twice before treatment, separated by 9 weeks, and once posttreatment. Telomerase activity and telomere length were measured in peripheral blood mononuclear cells and GPx activity in plasma. All patients contributed with complete data. Results showed that social anxiety symptom severity was significantly reduced from pretreatment to posttreatment (Cohen's d = 1.46). There were no significant alterations in telomeres or cellular protection markers before treatment onset. Telomere length and telomerase activity did not change significantly after treatment, but an increase in telomerase over treatment was associated with reduced social anxiety. Also, lower pretreatment telomerase activity predicted subsequent symptom improvement. GPx activity increased significantly during treatment, and increases were significantly associated with symptom improvement. The relationships between symptom improvement and putative protective enzymes remained significant also after controlling for body mass index, sex, duration of SAD, smoking, concurrent psychotropic medication, and the proportion of lymphocytes to monocytes. Thus, indices of cellular protection may be involved in the therapeutic mechanisms of psychological treatment for anxiety.

U2 - 10.1038/s41398-019-0668-2

DO - 10.1038/s41398-019-0668-2

M3 - Journal article

VL - 9

SP - 1

EP - 10

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

M1 - 340

ER -

ID: 58720521