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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Improved survival after allogeneic transplantation for acute lymphoblastic leukemia in adults: a Danish population-based study

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We investigated trends of survival in a population-based cohort study of all 181 adults who received HCT for ALL in Denmark between 2000-2019. Patients had a median (min-max) age of 36 (18-74) years at HCT and were followed for a median of eight years. Overall survival (OS) improved over time with an estimated 2-year OS of 49% (CI 27-66%) in year 2000 versus 77% (CI 59-88%) in year 2019. More patients achieved cure over time (OR for cure per year 1.07, CI 1.00-1.15), while the rate of death in non-cured patients remained stable (HR of excess mortality per year 0.99, CI 0.93-1.06). Relapse decreased over time (HR 0.92 per year, CI 0.87-0.98), whereas non-relapse mortality did not change notably (HR 0.98 per year, CI 0.93-1.04). In conclusion, survival after HCT in adults with ALL has improved over the past two decades, primarily due to more patients achieving cure.

Original languageEnglish
JournalLeukemia and Lymphoma
Volume63
Issue number2
Pages (from-to)416-425
Number of pages10
ISSN1042-8194
DOIs
Publication statusPublished - Feb 2022

    Research areas

  • acute lymphoblastic leukemia, ALL, allogeneic hematopoietic stem cell transplantation, Allogeneic transplantation, survival

ID: 69934084