Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma

Christian Mirian; Kathrine Grell; Tareq A Juratli; Felix Sahm; Sabine Spiegl-Kreinecker; Matthieu Peyre; Annamaria Biczok; Joerg Christian Tonn; Stéphane Goutagny; Luca Bertero; Andrea Daniela Maier; Lasse Rehné Jensen; Gabriele Schackert; Helle Broholm; David Scheie; Daniel P Cahill; Priscilla K Brastianos; Jane Skjøth-Rasmussen; Kåre Fugleholm; Morten Ziebell; Tina Nørgaard Munch; Bjarne Winther Kristensen; Tiit Mathiesen

doi:10.1111/nan.12773

Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma

Christian Mirian, Kathrine Grell, Tareq A Juratli, Felix Sahm, Sabine Spiegl-Kreinecker, Matthieu Peyre, Annamaria Biczok, Joerg Christian Tonn, Stéphane Goutagny, Luca Bertero, Andrea Daniela Maier, Lasse Rehné Jensen, Gabriele Schackert, Helle Broholm, David Scheie, Daniel P Cahill, Priscilla K Brastianos, Jane Skjøth-Rasmussen, Kåre Fugleholm, Morten ZiebellTina Nørgaard Munch, Bjarne Winther Kristensen, Tiit Mathiesen

Abstract

TERT promoter mutations have been associated with increased risk of recurrence in meningioma cohorts, thus a potential biomarker for aggressive phenotypes. A main purpose of refining tumour classification is better predictions on the patient level. We compiled data from previous published cohorts to investigate patient-level predictions of recurrence based on TERTp-mut status. Implementation of TERTp-mut into the WHO grading led to better patient prognostication by improved prediction of recurrence. Our results support implementation of TERTp-mut into diagnostics and classification of meningiomas.

Original language	English
Article number	e12773
Journal	Neuropathology and Applied Neurobiology
Volume	48
Issue number	3
Pages (from-to)	1-5
Number of pages	5
ISSN	0305-1846
DOIs	https://doi.org/10.1111/nan.12773
Publication status	Published - Apr 2022

Access to Document

10.1111/nan.12773

Cite this

Mirian, C., Grell, K., Juratli, T. A., Sahm, F., Spiegl-Kreinecker, S., Peyre, M., Biczok, A., Tonn, J. C., Goutagny, S., Bertero, L., Maier, A. D., Jensen, L. R., Schackert, G., Broholm, H., Scheie, D., Cahill, D. P., Brastianos, P. K., Skjøth-Rasmussen, J., Fugleholm, K., ... Mathiesen, T. (2022). Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma. Neuropathology and Applied Neurobiology, 48(3), 1-5. [e12773]. https://doi.org/10.1111/nan.12773

Mirian, C , Grell, K, Juratli, TA, Sahm, F, Spiegl-Kreinecker, S, Peyre, M, Biczok, A, Tonn, JC, Goutagny, S, Bertero, L, Maier, AD, Jensen, LR, Schackert, G, Broholm, H, Scheie, D, Cahill, DP, Brastianos, PK, Skjøth-Rasmussen, J , Fugleholm, K , Ziebell, M , Munch, TN , Kristensen, BW & Mathiesen, T 2022, 'Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma', Neuropathology and Applied Neurobiology, vol. 48, no. 3, e12773, pp. 1-5. https://doi.org/10.1111/nan.12773

@article{5d78fcf0e9864b39a540d16cbd78ed72,

title = "Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma",

abstract = "TERT promoter mutations have been associated with increased risk of recurrence in meningioma cohorts, thus a potential biomarker for aggressive phenotypes. A main purpose of refining tumour classification is better predictions on the patient level. We compiled data from previous published cohorts to investigate patient-level predictions of recurrence based on TERTp-mut status. Implementation of TERTp-mut into the WHO grading led to better patient prognostication by improved prediction of recurrence. Our results support implementation of TERTp-mut into diagnostics and classification of meningiomas.",

author = "Christian Mirian and Kathrine Grell and Juratli, {Tareq A} and Felix Sahm and Sabine Spiegl-Kreinecker and Matthieu Peyre and Annamaria Biczok and Tonn, {Joerg Christian} and St{\'e}phane Goutagny and Luca Bertero and Maier, {Andrea Daniela} and Jensen, {Lasse Rehn{\'e}} and Gabriele Schackert and Helle Broholm and David Scheie and Cahill, {Daniel P} and Brastianos, {Priscilla K} and Jane Skj{\o}th-Rasmussen and K{\aa}re Fugleholm and Morten Ziebell and Munch, {Tina N{\o}rgaard} and Kristensen, {Bjarne Winther} and Tiit Mathiesen",

year = "2022",

month = apr,

doi = "10.1111/nan.12773",

language = "English",

volume = "48",

pages = "1--5",

journal = "Neuropathology and Applied Neurobiology",

issn = "0305-1846",

publisher = "Wiley-Blackwell Publishing Ltd",

number = "3",

}

TY - JOUR

T1 - Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma

AU - Mirian, Christian

AU - Grell, Kathrine

AU - Juratli, Tareq A

AU - Sahm, Felix

AU - Spiegl-Kreinecker, Sabine

AU - Peyre, Matthieu

AU - Biczok, Annamaria

AU - Tonn, Joerg Christian

AU - Goutagny, Stéphane

AU - Bertero, Luca

AU - Maier, Andrea Daniela

AU - Jensen, Lasse Rehné

AU - Schackert, Gabriele

AU - Broholm, Helle

AU - Scheie, David

AU - Cahill, Daniel P

AU - Brastianos, Priscilla K

AU - Skjøth-Rasmussen, Jane

AU - Fugleholm, Kåre

AU - Ziebell, Morten

AU - Munch, Tina Nørgaard

AU - Kristensen, Bjarne Winther

AU - Mathiesen, Tiit

PY - 2022/4

Y1 - 2022/4

N2 - TERT promoter mutations have been associated with increased risk of recurrence in meningioma cohorts, thus a potential biomarker for aggressive phenotypes. A main purpose of refining tumour classification is better predictions on the patient level. We compiled data from previous published cohorts to investigate patient-level predictions of recurrence based on TERTp-mut status. Implementation of TERTp-mut into the WHO grading led to better patient prognostication by improved prediction of recurrence. Our results support implementation of TERTp-mut into diagnostics and classification of meningiomas.

AB - TERT promoter mutations have been associated with increased risk of recurrence in meningioma cohorts, thus a potential biomarker for aggressive phenotypes. A main purpose of refining tumour classification is better predictions on the patient level. We compiled data from previous published cohorts to investigate patient-level predictions of recurrence based on TERTp-mut status. Implementation of TERTp-mut into the WHO grading led to better patient prognostication by improved prediction of recurrence. Our results support implementation of TERTp-mut into diagnostics and classification of meningiomas.

UR - http://www.scopus.com/inward/record.url?scp=85120330490&partnerID=8YFLogxK

U2 - 10.1111/nan.12773

DO - 10.1111/nan.12773

M3 - Journal article

C2 - 34799864

VL - 48

SP - 1

EP - 5

JO - Neuropathology and Applied Neurobiology

JF - Neuropathology and Applied Neurobiology

SN - 0305-1846

IS - 3

M1 - e12773

ER -

Implementation of TERT promoter mutations improve prognostication of the WHO classification in meningioma

Abstract

Access to Document

Other files and links

Fingerprint

Cite this