Impaired incretin-induced amplification of insulin secretion after glucose homeostatic dysregulation in healthy subjects

45 Citations (Scopus)

Abstract

The insulinotropic effect of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide-1 (GLP-1) is impaired in patients with type 2 diabetes. It remains unclear whether this impairment is a primary pathophysiological trait or a consequence of developing diabetes. Therefore, we aimed to investigate the insulinotropic effect of GIP and GLP-1 compared with placebo before and after 12 d of glucose homeostatic dysregulation in healthy subjects.
Original languageEnglish
JournalJournal of Clinical Endocrinology and Metabolism
Volume97
Issue number4
Pages (from-to)1363-70
Number of pages8
ISSN0021-972X
DOIs
Publication statusPublished - 2012

Keywords

  • Adult
  • Blood Glucose
  • C-Peptide
  • Gastric Inhibitory Polypeptide
  • Glucagon
  • Glucagon-Like Peptide 1
  • Glucose Clamp Technique
  • Glucose Intolerance
  • Glucose Tolerance Test
  • Humans
  • Incretins
  • Infusions, Intravenous
  • Insulin
  • Insulin Resistance
  • Insulin-Secreting Cells
  • Kinetics
  • Male
  • Severity of Illness Index
  • Young Adult

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