Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD

Panu K. Luukkonen; You Zhou; P. A. Nidhina Haridas; Om P. Dwivedi; Tuulia Hyötyläinen; Ashfaq Ali; Anne Juuti; Marja Leivonen; Taru Tukiainen; Linda Ahonen; Emma Scott; Jeremy M. Palmer; Johanna Arola; Marju Orho-Melander; Petter Vikman; Quentin M. Anstee; Vesa M. Olkkonen; Matej Orešič; Leif Groop; Hannele Yki-Järvinen

doi:10.1016/j.jhep.2017.02.014

Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD

Panu K. Luukkonen, You Zhou, P. A. Nidhina Haridas, Om P. Dwivedi, Tuulia Hyötyläinen, Ashfaq Ali, Anne Juuti, Marja Leivonen, Taru Tukiainen, Linda Ahonen, Emma Scott, Jeremy M. Palmer, Johanna Arola, Marju Orho-Melander, Petter Vikman, Quentin M. Anstee, Vesa M. Olkkonen, Matej Orešič, Leif Groop, Hannele Yki-Järvinen

Steno Diabetes Center Copenhagen

120 Citations (Scopus)

Original language	English
Journal	Journal of Hepatology
Volume	67
Issue number	1
Pages (from-to)	128-136
Number of pages	9
ISSN	0168-8278
DOIs	https://doi.org/10.1016/j.jhep.2017.02.014
Publication status	Published - 1 Jul 2017

Keywords

Arachidonic acid
Cholesterol esters
Fatty acids
Genotype
Hepatocytes
Lipogenesis
Non-alcoholic fatty liver disease
Phosphatidylcholines
Transmembrane 6 superfamily member 2
Triglycerides

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Luukkonen, P. K., Zhou, Y., Nidhina Haridas, P. A., Dwivedi, O. P., Hyötyläinen, T., Ali, A., Juuti, A., Leivonen, M., Tukiainen, T., Ahonen, L., Scott, E., Palmer, J. M., Arola, J., Orho-Melander, M., Vikman, P., Anstee, Q. M., Olkkonen, V. M., Orešič, M., Groop, L., & Yki-Järvinen, H. (2017). Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD. Journal of Hepatology, 67(1), 128-136. https://doi.org/10.1016/j.jhep.2017.02.014

Luukkonen, PK, Zhou, Y, Nidhina Haridas, PA, Dwivedi, OP, Hyötyläinen, T, Ali, A, Juuti, A, Leivonen, M, Tukiainen, T, Ahonen, L, Scott, E, Palmer, JM, Arola, J, Orho-Melander, M, Vikman, P, Anstee, QM, Olkkonen, VM, Orešič, M, Groop, L & Yki-Järvinen, H 2017, 'Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD', Journal of Hepatology, vol. 67, no. 1, pp. 128-136. https://doi.org/10.1016/j.jhep.2017.02.014

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title = "Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD",

keywords = "Arachidonic acid, Cholesterol esters, Fatty acids, Genotype, Hepatocytes, Lipogenesis, Non-alcoholic fatty liver disease, Phosphatidylcholines, Transmembrane 6 superfamily member 2, Triglycerides",

author = "Luukkonen, \{Panu K.\} and You Zhou and \{Nidhina Haridas\}, \{P. A.\} and Dwivedi, \{Om P.\} and Tuulia Hy{\"o}tyl{\"a}inen and Ashfaq Ali and Anne Juuti and Marja Leivonen and Taru Tukiainen and Linda Ahonen and Emma Scott and Palmer, \{Jeremy M.\} and Johanna Arola and Marju Orho-Melander and Petter Vikman and Anstee, \{Quentin M.\} and Olkkonen, \{Vesa M.\} and Matej Ore{\v s}i{\v c} and Leif Groop and Hannele Yki-J{\"a}rvinen",

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doi = "10.1016/j.jhep.2017.02.014",

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T1 - Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD

AU - Luukkonen, Panu K.

AU - Zhou, You

AU - Nidhina Haridas, P. A.

AU - Dwivedi, Om P.

AU - Hyötyläinen, Tuulia

AU - Ali, Ashfaq

AU - Juuti, Anne

AU - Leivonen, Marja

AU - Tukiainen, Taru

AU - Ahonen, Linda

AU - Scott, Emma

AU - Palmer, Jeremy M.

AU - Arola, Johanna

AU - Orho-Melander, Marju

AU - Vikman, Petter

AU - Anstee, Quentin M.

AU - Olkkonen, Vesa M.

AU - Orešič, Matej

AU - Groop, Leif

AU - Yki-Järvinen, Hannele

PY - 2017/7/1

Y1 - 2017/7/1

KW - Arachidonic acid

KW - Cholesterol esters

KW - Fatty acids

KW - Genotype

KW - Hepatocytes

KW - Lipogenesis

KW - Non-alcoholic fatty liver disease

KW - Phosphatidylcholines

KW - Transmembrane 6 superfamily member 2

KW - Triglycerides

UR - https://www.scopus.com/pages/publications/85017448528

U2 - 10.1016/j.jhep.2017.02.014

DO - 10.1016/j.jhep.2017.02.014

M3 - Journal article

C2 - 28235613

AN - SCOPUS:85017448528

SN - 0168-8278

VL - 67

SP - 128

EP - 136

JO - Journal of Hepatology

JF - Journal of Hepatology

IS - 1

ER -

Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD

Keywords

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