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Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study

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Grønhøj, Christian ; Jensen, Jakob Schmidt ; Wagner, Steffen ; Dehlendorff, Christian ; Friborg, Jeppe ; Andersen, Elo ; Wittekindt, Claus ; Würdemann, Nora ; Sharma, Shachi Jenny ; Gattenlöhner, Stefan ; Klussmann, Jens Peter ; von Buchwald, Christian. / Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status : a multicenter retrospective study. In: Oncotarget. 2019 ; Vol. 10, No. 45. pp. 4655-4663.

Bibtex

@article{4239a9ed92674664ac1812d3027c3cf6,
title = "Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status: a multicenter retrospective study",
abstract = "Background: Human papilloma virus (HPV) and tobacco smoking are important risk factors for development of oropharyngeal squamous cell carcinoma (OPSCC).Aims/objectives: To evaluate the impact of tobacco smoking on survival for cases with OPSCC with known HPV- and p16INK4A(p16)-status.Materials and Methods: OPSCC cases at the University Hospital of Copenhagen, Rigshospitalet, Denmark (2000-2014) and at University Hospital of Giessen, Germany (2000-2009) were included. Survival was illustrated with Kaplan-Meier plots. The effect of smoking exposure on survival was evaluated by Cox-regression models. HPV-positivity was defined as positivity for both HPV-DNA and p16.Results: We included 1316 OPSCC cases from 2000-2014 (48% HPV-positive). Smokers had a poorer outcome compared to non-smokers. Considering continuous smoking exposure, adding 10 pack-years of smoking increased hazard ratios irrespective of HPV-status.We observed a tendency to a greater impact on survival for cases with HPV-neg. tumours compared to cases with HPV-pos. tumours at low numbers of pack-years, yet the survival was similar at high numbers of pack-years. There was no significant difference in the impact of HPV-status on survival for non-smokers, however a highly significant difference for smokers.Conclusions and Significance: Smoking-status and number of pack-years at time of diagnosis impact survival for cases with OPSCC independent of HPV-status.",
author = "Christian Gr{\o}nh{\o}j and Jensen, {Jakob Schmidt} and Steffen Wagner and Christian Dehlendorff and Jeppe Friborg and Elo Andersen and Claus Wittekindt and Nora W{\"u}rdemann and Sharma, {Shachi Jenny} and Stefan Gattenl{\"o}hner and Klussmann, {Jens Peter} and {von Buchwald}, Christian",
year = "2019",
month = jul,
day = "23",
doi = "10.18632/oncotarget.27079",
language = "English",
volume = "10",
pages = "4655--4663",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals LLC",
number = "45",

}

RIS

TY - JOUR

T1 - Impact on survival of tobacco smoking for cases with oropharyngeal squamous cell carcinoma and known human papillomavirus and p16-status

T2 - a multicenter retrospective study

AU - Grønhøj, Christian

AU - Jensen, Jakob Schmidt

AU - Wagner, Steffen

AU - Dehlendorff, Christian

AU - Friborg, Jeppe

AU - Andersen, Elo

AU - Wittekindt, Claus

AU - Würdemann, Nora

AU - Sharma, Shachi Jenny

AU - Gattenlöhner, Stefan

AU - Klussmann, Jens Peter

AU - von Buchwald, Christian

PY - 2019/7/23

Y1 - 2019/7/23

N2 - Background: Human papilloma virus (HPV) and tobacco smoking are important risk factors for development of oropharyngeal squamous cell carcinoma (OPSCC).Aims/objectives: To evaluate the impact of tobacco smoking on survival for cases with OPSCC with known HPV- and p16INK4A(p16)-status.Materials and Methods: OPSCC cases at the University Hospital of Copenhagen, Rigshospitalet, Denmark (2000-2014) and at University Hospital of Giessen, Germany (2000-2009) were included. Survival was illustrated with Kaplan-Meier plots. The effect of smoking exposure on survival was evaluated by Cox-regression models. HPV-positivity was defined as positivity for both HPV-DNA and p16.Results: We included 1316 OPSCC cases from 2000-2014 (48% HPV-positive). Smokers had a poorer outcome compared to non-smokers. Considering continuous smoking exposure, adding 10 pack-years of smoking increased hazard ratios irrespective of HPV-status.We observed a tendency to a greater impact on survival for cases with HPV-neg. tumours compared to cases with HPV-pos. tumours at low numbers of pack-years, yet the survival was similar at high numbers of pack-years. There was no significant difference in the impact of HPV-status on survival for non-smokers, however a highly significant difference for smokers.Conclusions and Significance: Smoking-status and number of pack-years at time of diagnosis impact survival for cases with OPSCC independent of HPV-status.

AB - Background: Human papilloma virus (HPV) and tobacco smoking are important risk factors for development of oropharyngeal squamous cell carcinoma (OPSCC).Aims/objectives: To evaluate the impact of tobacco smoking on survival for cases with OPSCC with known HPV- and p16INK4A(p16)-status.Materials and Methods: OPSCC cases at the University Hospital of Copenhagen, Rigshospitalet, Denmark (2000-2014) and at University Hospital of Giessen, Germany (2000-2009) were included. Survival was illustrated with Kaplan-Meier plots. The effect of smoking exposure on survival was evaluated by Cox-regression models. HPV-positivity was defined as positivity for both HPV-DNA and p16.Results: We included 1316 OPSCC cases from 2000-2014 (48% HPV-positive). Smokers had a poorer outcome compared to non-smokers. Considering continuous smoking exposure, adding 10 pack-years of smoking increased hazard ratios irrespective of HPV-status.We observed a tendency to a greater impact on survival for cases with HPV-neg. tumours compared to cases with HPV-pos. tumours at low numbers of pack-years, yet the survival was similar at high numbers of pack-years. There was no significant difference in the impact of HPV-status on survival for non-smokers, however a highly significant difference for smokers.Conclusions and Significance: Smoking-status and number of pack-years at time of diagnosis impact survival for cases with OPSCC independent of HPV-status.

U2 - 10.18632/oncotarget.27079

DO - 10.18632/oncotarget.27079

M3 - Journal article

C2 - 31384393

VL - 10

SP - 4655

EP - 4663

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 45

ER -

ID: 58346250