Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty

Kaspar Sørensen; Lise Aksglaede; Thor Munch-Andersen; Niels Jacob Aachmann-Andersen; Henrik Leffers; Jørn Wulff Helge; Linda Hilsted; Anders Juul

doi:10.1210/jc.2009-0313

Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty

Kaspar Sørensen, Lise Aksglaede, Thor Munch-Andersen, Niels Jacob Aachmann-Andersen, Henrik Leffers, Jørn Wulff Helge, Linda Hilsted, Anders Juul

26 Citations (Scopus)

Abstract

The GH/IGF-I axis has major impact on insulin sensitivity and insulin secretion. Recently a polymorphism in the GH receptor gene (GHR), a genomic deletion of exon 3 (GHRd3), has been linked to increased responsiveness to GH.

Original language	English
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	94
Issue number	8
Pages (from-to)	2966-9
Number of pages	4
ISSN	0021-972X
DOIs	https://doi.org/10.1210/jc.2009-0313
Publication status	Published - 2009
Externally published	Yes

Keywords

Adolescent
Alleles
Child
Cross-Sectional Studies
Exons
Female
Gene Deletion
Glucose
Humans
Insulin
Insulin-Like Growth Factor I
Male
Polymorphism, Genetic
Puberty
Receptors, Somatotropin
Triglycerides

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10.1210/jc.2009-0313

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Sørensen, K., Aksglaede, L., Munch-Andersen, T., Aachmann-Andersen, N. J., Leffers, H., Helge, J. W., Hilsted, L., & Juul, A. (2009). Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty. Journal of Clinical Endocrinology and Metabolism, 94(8), 2966-9. https://doi.org/10.1210/jc.2009-0313

Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty. / Sørensen, Kaspar; Aksglaede, Lise; Munch-Andersen, Thor et al.
In: Journal of Clinical Endocrinology and Metabolism, Vol. 94, No. 8, 2009, p. 2966-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Sørensen, K, Aksglaede, L, Munch-Andersen, T, Aachmann-Andersen, NJ, Leffers, H, Helge, JW, Hilsted, L & Juul, A 2009, 'Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty', Journal of Clinical Endocrinology and Metabolism, vol. 94, no. 8, pp. 2966-9. https://doi.org/10.1210/jc.2009-0313

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abstract = "The GH/IGF-I axis has major impact on insulin sensitivity and insulin secretion. Recently a polymorphism in the GH receptor gene (GHR), a genomic deletion of exon 3 (GHRd3), has been linked to increased responsiveness to GH.",

keywords = "Adolescent, Alleles, Child, Cross-Sectional Studies, Exons, Female, Gene Deletion, Glucose, Humans, Insulin, Insulin-Like Growth Factor I, Male, Polymorphism, Genetic, Puberty, Receptors, Somatotropin, Triglycerides",

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AU - Sørensen, Kaspar

AU - Aksglaede, Lise

AU - Munch-Andersen, Thor

AU - Aachmann-Andersen, Niels Jacob

AU - Leffers, Henrik

AU - Helge, Jørn Wulff

AU - Hilsted, Linda

AU - Juul, Anders

PY - 2009

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N2 - The GH/IGF-I axis has major impact on insulin sensitivity and insulin secretion. Recently a polymorphism in the GH receptor gene (GHR), a genomic deletion of exon 3 (GHRd3), has been linked to increased responsiveness to GH.

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KW - Adolescent

KW - Alleles

KW - Child

KW - Cross-Sectional Studies

KW - Exons

KW - Female

KW - Gene Deletion

KW - Glucose

KW - Humans

KW - Insulin

KW - Insulin-Like Growth Factor I

KW - Male

KW - Polymorphism, Genetic

KW - Puberty

KW - Receptors, Somatotropin

KW - Triglycerides

U2 - 10.1210/jc.2009-0313

DO - 10.1210/jc.2009-0313

M3 - Journal article

C2 - 19417039

SN - 0021-972X

VL - 94

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EP - 2969

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 8

ER -

Impact of the growth hormone receptor exon 3 deletion gene polymorphism on glucose metabolism, lipids, and insulin-like growth factor-I levels during puberty

Abstract

Keywords

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