Impact of symptomatic deep vein thrombosis on self-reported function and treatment outcome following an acute Achilles tendon rupture: A register study

Jacob S Gandløse; Kristoffer W Barfod; Rikke Hoeffner; Maria Swennergren Hansen; Marianne Christensen; Henrik Riel

doi:10.1016/j.fas.2025.02.002

Impact of symptomatic deep vein thrombosis on self-reported function and treatment outcome following an acute Achilles tendon rupture: A register study

Jacob S Gandløse^*, Kristoffer W Barfod, Rikke Hoeffner, Maria Swennergren Hansen, Marianne Christensen, Henrik Riel

^*Corresponding author for this work

Abstract

BACKGROUND: Acute Achilles tendon rupture (ATR) is a common injury associated with a high rate of deep vein thrombosis (DVT) during rehabilitation. This study assessed whether DVT affects long-term self-reported function.

METHODS: Data from the Danish Achilles Tendon Database were used to compare Achilles tendon Total Rupture Scores (ATRS) at 6, 12, and 24 months between patients with and without symptomatic DVT, adjusting for covariates.

RESULTS: No significant ATRS difference between DVT and non-DVT groups was observed over time (adjusted mean difference = -0.7, 95 % CI: -4.8-3.3, p = 0.72). However, patients with DVT reported lower ATRS at 24 months (adjusted mean difference = -4.9, 95 % CI: -9.0 to -0.9, p = 0.02).

CONCLUSIONS: Symptomatic DVT is not significantly associated with self-reported function over time in patients with ATR. However, patients with DVT may experience a recovery plateau, leading to lower long-term function, though the clinical significance is unclear.

Original language	English
Journal	Foot and Ankle Surgery
Volume	31
Issue number	6
Pages (from-to)	498-504
Number of pages	7
ISSN	1268-7731
DOIs	https://doi.org/10.1016/j.fas.2025.02.002
Publication status	Published - Aug 2025

Keywords

Achilles Tendon/injuries
Adult
Denmark
Female
Humans
Male
Middle Aged
Orthopedic Fixation Devices/adverse effects
Recovery of Function
Registries/statistics & numerical data
Rupture/complications
Self Report/statistics & numerical data
Treatment Outcome
Venous Thrombosis/epidemiology
Deep Vein Thrombosis
Achilles tendon Total Rupture Score
Achilles tendon rupture

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Impact of symptomatic deep vein thrombosis on self-reported function and treatment outcome following an acute Achilles tendon rupture: A register study. / Gandløse, Jacob S; Barfod, Kristoffer W ; Hoeffner, Rikke et al.
In: Foot and Ankle Surgery, Vol. 31, No. 6, 08.2025, p. 498-504.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Impact of symptomatic deep vein thrombosis on self-reported function and treatment outcome following an acute Achilles tendon rupture: A register study",

abstract = "BACKGROUND: Acute Achilles tendon rupture (ATR) is a common injury associated with a high rate of deep vein thrombosis (DVT) during rehabilitation. This study assessed whether DVT affects long-term self-reported function.METHODS: Data from the Danish Achilles Tendon Database were used to compare Achilles tendon Total Rupture Scores (ATRS) at 6, 12, and 24 months between patients with and without symptomatic DVT, adjusting for covariates.RESULTS: No significant ATRS difference between DVT and non-DVT groups was observed over time (adjusted mean difference = -0.7, 95 \% CI: -4.8-3.3, p = 0.72). However, patients with DVT reported lower ATRS at 24 months (adjusted mean difference = -4.9, 95 \% CI: -9.0 to -0.9, p = 0.02).CONCLUSIONS: Symptomatic DVT is not significantly associated with self-reported function over time in patients with ATR. However, patients with DVT may experience a recovery plateau, leading to lower long-term function, though the clinical significance is unclear.",

keywords = "Achilles Tendon/injuries, Adult, Denmark, Female, Humans, Male, Middle Aged, Orthopedic Fixation Devices/adverse effects, Recovery of Function, Registries/statistics \& numerical data, Rupture/complications, Self Report/statistics \& numerical data, Treatment Outcome, Venous Thrombosis/epidemiology, Deep Vein Thrombosis, Achilles tendon Total Rupture Score, Achilles tendon rupture",

author = "Gandl{\o}se, \{Jacob S\} and Barfod, \{Kristoffer W\} and Rikke Hoeffner and Hansen, \{Maria Swennergren\} and Marianne Christensen and Henrik Riel",

year = "2025",

month = aug,

doi = "10.1016/j.fas.2025.02.002",

language = "English",

volume = "31",

pages = "498--504",

journal = "Foot and Ankle Surgery",

issn = "1268-7731",

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number = "6",

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T1 - Impact of symptomatic deep vein thrombosis on self-reported function and treatment outcome following an acute Achilles tendon rupture

T2 - A register study

AU - Gandløse, Jacob S

AU - Barfod, Kristoffer W

AU - Hoeffner, Rikke

AU - Hansen, Maria Swennergren

AU - Christensen, Marianne

AU - Riel, Henrik

PY - 2025/8

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N2 - BACKGROUND: Acute Achilles tendon rupture (ATR) is a common injury associated with a high rate of deep vein thrombosis (DVT) during rehabilitation. This study assessed whether DVT affects long-term self-reported function.METHODS: Data from the Danish Achilles Tendon Database were used to compare Achilles tendon Total Rupture Scores (ATRS) at 6, 12, and 24 months between patients with and without symptomatic DVT, adjusting for covariates.RESULTS: No significant ATRS difference between DVT and non-DVT groups was observed over time (adjusted mean difference = -0.7, 95 % CI: -4.8-3.3, p = 0.72). However, patients with DVT reported lower ATRS at 24 months (adjusted mean difference = -4.9, 95 % CI: -9.0 to -0.9, p = 0.02).CONCLUSIONS: Symptomatic DVT is not significantly associated with self-reported function over time in patients with ATR. However, patients with DVT may experience a recovery plateau, leading to lower long-term function, though the clinical significance is unclear.

AB - BACKGROUND: Acute Achilles tendon rupture (ATR) is a common injury associated with a high rate of deep vein thrombosis (DVT) during rehabilitation. This study assessed whether DVT affects long-term self-reported function.METHODS: Data from the Danish Achilles Tendon Database were used to compare Achilles tendon Total Rupture Scores (ATRS) at 6, 12, and 24 months between patients with and without symptomatic DVT, adjusting for covariates.RESULTS: No significant ATRS difference between DVT and non-DVT groups was observed over time (adjusted mean difference = -0.7, 95 % CI: -4.8-3.3, p = 0.72). However, patients with DVT reported lower ATRS at 24 months (adjusted mean difference = -4.9, 95 % CI: -9.0 to -0.9, p = 0.02).CONCLUSIONS: Symptomatic DVT is not significantly associated with self-reported function over time in patients with ATR. However, patients with DVT may experience a recovery plateau, leading to lower long-term function, though the clinical significance is unclear.

KW - Achilles Tendon/injuries

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KW - Humans

KW - Male

KW - Middle Aged

KW - Orthopedic Fixation Devices/adverse effects

KW - Recovery of Function

KW - Registries/statistics & numerical data

KW - Rupture/complications

KW - Self Report/statistics & numerical data

KW - Treatment Outcome

KW - Venous Thrombosis/epidemiology

KW - Deep Vein Thrombosis

KW - Achilles tendon Total Rupture Score

KW - Achilles tendon rupture

UR - https://www.scopus.com/pages/publications/85217809028

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DO - 10.1016/j.fas.2025.02.002

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C2 - 39947959

SN - 1268-7731

VL - 31

SP - 498

EP - 504

JO - Foot and Ankle Surgery

JF - Foot and Ankle Surgery

IS - 6

ER -

Impact of symptomatic deep vein thrombosis on self-reported function and treatment outcome following an acute Achilles tendon rupture: A register study

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