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Impact of screening on short-term mortality and morbidity following treatment for colorectal cancer

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BACKGROUND AND OBJECTIVE: The aim of this study was to describe short-term changes in morbidity and mortality associated with the implementation of screening for colorectal cancer in Denmark.

METHODS: Prospective cohort study with inclusion of all patients aged 50-75 years treated for colorectal cancer between 1 March 2014 and 31 December 2015 in Denmark. Adjusted hazard ratios were calculated for 30 and 90 days mortality using Cox Regression. We made two adjusted models-a "basic" adjusted for screening status, sex, age, smoking, alcohol consumption, and cancer type and an "advanced" that also included body mass index and American society of Anesthesiologists score in analyses. Relative risks were calculated for postoperative surgical and medical complications.

RESULTS: In total, 5348 patients were included. In the "basic model," adjusted risk of 30 and 90 days total mortality was reduced in the screen-detected group (p < 0.01, HR = 0.43, CI = 0.24-0.76) and (p < 0.01, HR = 0.45, CI = 0.30-0.69). In the "advanced model," only 90 days total mortality was significantly reduced in the screen-detected group (p = 0.01, HR 0.59, CI = 0.39-0.90). No significant changes were found with regard to surgical and medical complications, respectively, (p = 0.05 (CI = 0.76-1.00) and p = 0.47(CI = 0.74-1.15)).

CONCLUSIONS: This nationwide study showed that screening for colorectal cancer was associated with a lower 90 days total mortality although no significant improvements were seen with regard to morbidity.

Original languageEnglish
Article number14574969211019824
JournalScandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society
Volume110
Issue number4
Pages (from-to)465-471
Number of pages7
ISSN1457-4969
DOIs
Publication statusPublished - Dec 2021

Bibliographical note

Publisher Copyright:
© The Finnish Surgical Society 2021.

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

    Research areas

  • CRC, screening, short-term outcomes, surgery

ID: 66134767