Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Impact of pretreatment interhemispheric hippocampal asymmetry on improvement in verbal learning following erythropoietin treatment in mood disorders: a randomized controlled trial

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Altered response to risky decisions and reward in patients with obsessive–compulsive disorder

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Neural response to emotional faces in monozygotic twins: association with familial risk of affective disorders

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Anti-inflammatory treatment and risk for depression after first-time stroke in a cohort of 147 487 Danish patients

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. A Contrast-Adaptive Method for Simultaneous Whole-Brain and Lesion Segmentation in Multiple Sclerosis

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Daily mobility patterns in patients with bipolar disorder and healthy individuals

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Background: Treatment development that targets cognitive impairment is hampered by a lack of biomarkers that can predict treatment effi-cacy. Erythropoietin (EPO) improves verbal learning and memory in mood disorders, and this scales with an increase in left hippocampal volume. This study investigated whether pretreatment left hippocampal volume, interhemisphere hippocampal asymmetry or both influ-enced EPO treatment response with respect to verbal learning. Methods: Data were available for 76 of 83 patients with mood disorders from our previous EPO trials (EPO = 37 patients; placebo = 39 patients). We performed cortical reconstruction and volumetric segmentation using FreeSurfer. We conducted multiple linear regression and logistic regression to assess the influence of left hippocampal volume and hippocampal asymmetry on EPO-related memory improvement, as reflected by change in Rey Auditory Verbal Learning Test total recall from baseline to post-treatment. We set up a corresponding exploratory general linear model in FreeSurfer to assess the influence of pre-frontal cortex volume on verbal learning improvement, controlling for age, sex and total intracranial volume. Results: At baseline, more rightward (left < right) hippocampal asymmetry — but not left hippocampal volume per se — was associated with greater effects of EPO versus placebo on verbal learning (p ≤ 0.05). Exploratory analysis indicated that a larger left precentral gyrus surface area was also associated with improvement of verbal learning in the EPO group compared to the placebo group (p = 0.002). Limitations: This was a secondary analysis of our original EPO trials. Conclusion: Rightward hippocampal asymmetry may convey a positive effect of EPO treatment efficacy on verbal learning. Clinical trial registration: Clinicaltrials.gov NCT00916552.

Original languageEnglish
Article number180205
JournalJournal of psychiatry & neuroscience : JPN
Volume45
Issue number3
Pages (from-to)198-205
Number of pages8
ISSN1180-4882
DOIs
Publication statusPublished - 1 May 2020

Bibliographical note

© 2020 Joule Inc. or its licensors

ID: 58520487