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Impact of mean arterial pressure on sublingual microcirculation during cardiopulmonary bypass - secondary outcome from a randomised clinical trial

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@article{5eed88bbfc804bd58a62ced3daf38512,
title = "Impact of mean arterial pressure on sublingual microcirculation during cardiopulmonary bypass - secondary outcome from a randomised clinical trial",
abstract = "OBJECTIVE: In this substudy of a randomised, clinical trial, we explored the sublingual microcirculation during cardiac surgery at two different levels of blood pressure. We hypothesised that a higher mean arterial pressure during cardiopulmonary bypass would cause higher Microvascular Flow Index.METHODS: Thirty-six cardiac surgery patients undergoing coronary artery bypass grafting were included and randomised to either low (40-50 mmHg) or high (70-80 mmHg) mean arterial pressure during cardiopulmonary bypass. Sidestream Dark Field video images were recorded from the sublingual mucosa. Recordings were analysed in a blinded fashion to quantify microcirculatory variables.RESULTS: Mean arterial pressure during cardiopulmonary bypass in the low target group was 45.0 mmHg (SD 5.3) vs. 67.2 mmHg (SD 8.9) in the high target group. We found no significant difference between the two groups in Microvascular Flow Index during cardiopulmonary bypass evaluated for all vessels: 2.91 vs. 2.90 (p = 0.82). For small vessels (< 20 micrometers), the corresponding values were 2.87 and 2.85 in the low and high target groups, respectively (p = 0.82).CONCLUSIONS: We found no significant difference in sublingual microcirculatory flow expressed as Microvascular Flow Index according to two different levels of mean arterial pressure during cardiopulmonary bypass. This article is protected by copyright. All rights reserved.",
keywords = "Journal Article",
author = "Frederik Holmgaard and Vedel, {Anne G} and Ravn, {Hanne Berg} and Nilsson, {Jens C} and Rasmussen, {Lars S}",
note = "This article is protected by copyright. All rights reserved.",
year = "2018",
doi = "10.1111/micc.12459",
language = "English",
volume = "25",
pages = "e12459",
journal = "Microcirculation Review",
issn = "0168-1745",
publisher = "Springer Netherlands",
number = "5",

}

RIS

TY - JOUR

T1 - Impact of mean arterial pressure on sublingual microcirculation during cardiopulmonary bypass - secondary outcome from a randomised clinical trial

AU - Holmgaard, Frederik

AU - Vedel, Anne G

AU - Ravn, Hanne Berg

AU - Nilsson, Jens C

AU - Rasmussen, Lars S

N1 - This article is protected by copyright. All rights reserved.

PY - 2018

Y1 - 2018

N2 - OBJECTIVE: In this substudy of a randomised, clinical trial, we explored the sublingual microcirculation during cardiac surgery at two different levels of blood pressure. We hypothesised that a higher mean arterial pressure during cardiopulmonary bypass would cause higher Microvascular Flow Index.METHODS: Thirty-six cardiac surgery patients undergoing coronary artery bypass grafting were included and randomised to either low (40-50 mmHg) or high (70-80 mmHg) mean arterial pressure during cardiopulmonary bypass. Sidestream Dark Field video images were recorded from the sublingual mucosa. Recordings were analysed in a blinded fashion to quantify microcirculatory variables.RESULTS: Mean arterial pressure during cardiopulmonary bypass in the low target group was 45.0 mmHg (SD 5.3) vs. 67.2 mmHg (SD 8.9) in the high target group. We found no significant difference between the two groups in Microvascular Flow Index during cardiopulmonary bypass evaluated for all vessels: 2.91 vs. 2.90 (p = 0.82). For small vessels (< 20 micrometers), the corresponding values were 2.87 and 2.85 in the low and high target groups, respectively (p = 0.82).CONCLUSIONS: We found no significant difference in sublingual microcirculatory flow expressed as Microvascular Flow Index according to two different levels of mean arterial pressure during cardiopulmonary bypass. This article is protected by copyright. All rights reserved.

AB - OBJECTIVE: In this substudy of a randomised, clinical trial, we explored the sublingual microcirculation during cardiac surgery at two different levels of blood pressure. We hypothesised that a higher mean arterial pressure during cardiopulmonary bypass would cause higher Microvascular Flow Index.METHODS: Thirty-six cardiac surgery patients undergoing coronary artery bypass grafting were included and randomised to either low (40-50 mmHg) or high (70-80 mmHg) mean arterial pressure during cardiopulmonary bypass. Sidestream Dark Field video images were recorded from the sublingual mucosa. Recordings were analysed in a blinded fashion to quantify microcirculatory variables.RESULTS: Mean arterial pressure during cardiopulmonary bypass in the low target group was 45.0 mmHg (SD 5.3) vs. 67.2 mmHg (SD 8.9) in the high target group. We found no significant difference between the two groups in Microvascular Flow Index during cardiopulmonary bypass evaluated for all vessels: 2.91 vs. 2.90 (p = 0.82). For small vessels (< 20 micrometers), the corresponding values were 2.87 and 2.85 in the low and high target groups, respectively (p = 0.82).CONCLUSIONS: We found no significant difference in sublingual microcirculatory flow expressed as Microvascular Flow Index according to two different levels of mean arterial pressure during cardiopulmonary bypass. This article is protected by copyright. All rights reserved.

KW - Journal Article

U2 - 10.1111/micc.12459

DO - 10.1111/micc.12459

M3 - Journal article

C2 - 29754402

VL - 25

SP - e12459

JO - Microcirculation Review

JF - Microcirculation Review

SN - 0168-1745

IS - 5

ER -

ID: 53752684