Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation

F Baron; M Labopin; D Niederwieser; S Vigouroux; Joep Cornelissen; C Malm; L L Vindelov; D Blaise; J J W M Janssen; E Petersen; G Socié; A Nagler; V Rocha; M Mohty

doi:10.1038/leu.2012.135

Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation

F Baron, M Labopin, D Niederwieser, S Vigouroux, Joep Cornelissen, C Malm, L L Vindelov, D Blaise, J J W M Janssen, E Petersen, G Socié, A Nagler, V Rocha, M Mohty

163 Citations (Scopus)

Abstract

This report investigated the impact of graft-versus-host disease (GVHD) on transplantation outcomes in 1859 acute myeloid leukemia patients given allogeneic peripheral blood stem cells after reduced-intensity conditioning (RIC allo-SCT). Grade I acute GVHD was associated with a lower risk of relapse (hazards ratio (HR)=0.7, P=0.02) translating into a trend for better overall survival (OS; HR=1.3; P=0.07). Grade II acute GVHD had no net impact on OS, while grade III-IV acute GVHD was associated with a worse OS (HR=0.4, P

Original language	English
Journal	Leukemia
Volume	26
Issue number	12
Pages (from-to)	2462-8
Number of pages	7
ISSN	0887-6924
DOIs	https://doi.org/10.1038/leu.2012.135
Publication status	Published - 2012

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Baron, F., Labopin, M., Niederwieser, D., Vigouroux, S., Cornelissen, J., Malm, C., Vindelov, L. L., Blaise, D., Janssen, J. J. W. M., Petersen, E., Socié, G., Nagler, A., Rocha, V., & Mohty, M. (2012). Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation. Leukemia, 26(12), 2462-8. https://doi.org/10.1038/leu.2012.135

Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation. / Baron, F; Labopin, M; Niederwieser, D et al.
In: Leukemia, Vol. 26, No. 12, 2012, p. 2462-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Baron, F, Labopin, M, Niederwieser, D, Vigouroux, S, Cornelissen, J, Malm, C, Vindelov, LL, Blaise, D, Janssen, JJWM, Petersen, E, Socié, G, Nagler, A, Rocha, V & Mohty, M 2012, 'Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation', Leukemia, vol. 26, no. 12, pp. 2462-8. https://doi.org/10.1038/leu.2012.135

Baron F, Labopin M, Niederwieser D, Vigouroux S, Cornelissen J, Malm C et al. Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation. Leukemia. 2012;26(12):2462-8. doi: 10.1038/leu.2012.135

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Impact of graft-versus-host disease after reduced-intensity conditioning allogeneic stem cell transplantation for acute myeloid leukemia: a report from the Acute Leukemia Working Party of the European group for blood and marrow transplantation

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