Impact of glycaemic control on the effect of direct renin inhibition in the AVOID study

Frederik Persson; Julia B Lewis; Edmund J Lewis; Peter Rossing; Norman K Hollenberg; Hans-Henrik Parving

doi:10.1177/1470320312437068

Impact of glycaemic control on the effect of direct renin inhibition in the AVOID study

Frederik Persson, Julia B Lewis, Edmund J Lewis, Peter Rossing, Norman K Hollenberg, Hans-Henrik Parving

3 Citations (Scopus)

Abstract

Hyperglycaemia induces development and progression of microvascular complications in diabetes. A direct link between high glucose levels and intrarenal renin-angiotensin activation has been demonstrated. This post-hoc analysis assessed the influence of baseline glycaemic control on the reduction of albuminuria with aliskiren or placebo added to losartan in the Aliskiren in the EValuation of PrOteinuria In Diabetes (AVOID) study.

Original language	English
Journal	Journal of the Renin-Angiotensin-Aldosterone System
Volume	13
Issue number	2
Pages (from-to)	250-3
Number of pages	4
ISSN	1470-3203
DOIs	https://doi.org/10.1177/1470320312437068
Publication status	Published - 2012

Keywords

Adolescent
Adult
Aged
Aged, 80 and over
Amides
Body Mass Index
Diabetes Complications
Female
Fumarates
Health Surveys
Hemoglobin A, Glycosylated
Humans
Hyperglycemia
Hypoglycemic Agents
Male
Middle Aged
Placebos
Proteinuria
Renin
Young Adult

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10.1177/1470320312437068

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title = "Impact of glycaemic control on the effect of direct renin inhibition in the AVOID study",

abstract = "Hyperglycaemia induces development and progression of microvascular complications in diabetes. A direct link between high glucose levels and intrarenal renin-angiotensin activation has been demonstrated. This post-hoc analysis assessed the influence of baseline glycaemic control on the reduction of albuminuria with aliskiren or placebo added to losartan in the Aliskiren in the EValuation of PrOteinuria In Diabetes (AVOID) study.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Amides, Body Mass Index, Diabetes Complications, Female, Fumarates, Health Surveys, Hemoglobin A, Glycosylated, Humans, Hyperglycemia, Hypoglycemic Agents, Male, Middle Aged, Placebos, Proteinuria, Renin, Young Adult",

author = "Frederik Persson and Lewis, \{Julia B\} and Lewis, \{Edmund J\} and Peter Rossing and Hollenberg, \{Norman K\} and Hans-Henrik Parving",

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language = "English",

volume = "13",

pages = "250--3",

journal = "Journal of the Renin-Angiotensin-Aldosterone System",

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T1 - Impact of glycaemic control on the effect of direct renin inhibition in the AVOID study

AU - Persson, Frederik

AU - Lewis, Julia B

AU - Lewis, Edmund J

AU - Rossing, Peter

AU - Hollenberg, Norman K

AU - Parving, Hans-Henrik

PY - 2012

Y1 - 2012

N2 - Hyperglycaemia induces development and progression of microvascular complications in diabetes. A direct link between high glucose levels and intrarenal renin-angiotensin activation has been demonstrated. This post-hoc analysis assessed the influence of baseline glycaemic control on the reduction of albuminuria with aliskiren or placebo added to losartan in the Aliskiren in the EValuation of PrOteinuria In Diabetes (AVOID) study.

AB - Hyperglycaemia induces development and progression of microvascular complications in diabetes. A direct link between high glucose levels and intrarenal renin-angiotensin activation has been demonstrated. This post-hoc analysis assessed the influence of baseline glycaemic control on the reduction of albuminuria with aliskiren or placebo added to losartan in the Aliskiren in the EValuation of PrOteinuria In Diabetes (AVOID) study.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Amides

KW - Body Mass Index

KW - Diabetes Complications

KW - Female

KW - Fumarates

KW - Health Surveys

KW - Hemoglobin A, Glycosylated

KW - Humans

KW - Hyperglycemia

KW - Hypoglycemic Agents

KW - Male

KW - Middle Aged

KW - Placebos

KW - Proteinuria

KW - Renin

KW - Young Adult

UR - https://www.scopus.com/pages/publications/84861843421

U2 - 10.1177/1470320312437068

DO - 10.1177/1470320312437068

M3 - Journal article

C2 - 22345094

SN - 1470-3203

VL - 13

SP - 250

EP - 253

JO - Journal of the Renin-Angiotensin-Aldosterone System

JF - Journal of the Renin-Angiotensin-Aldosterone System

IS - 2

ER -

Impact of glycaemic control on the effect of direct renin inhibition in the AVOID study

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Keywords

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