Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Impact of genetic polymorphism in the β₂-receptor gene on risk of severe hypoglycemia in patients with type 1 diabetes

Research output: Contribution to journalJournal articleResearchpeer-review

DOI

  1. Expression of cholecystokinin and its receptors in the intestinal tract of type 2 diabetes patients and healthy controls

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Elevated apolipoprotein A1 and HDL cholesterol associated with age-related macular degeneration: 2 population cohorts

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Prenatal Exposure to Butyl Paraben Is Associated With Fat Percentage in 7-Year-Old Boys

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Serum insulin-like factor 3 levels are reduced in former androgen users suggesting impaired Leydig cell capacity

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Treatment of Hyperthyroidism Reduces Systemic Oxidative Stress, as Measured by Markers of RNA and DNA Damage

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Does nocturnal hypoglycaemia really improve quality of life? Reply to Søholm U, Broadley MM, Choudhary P et al [letter]

    Research output: Contribution to journalLetterResearchpeer-review

  2. Acute hypoglycemia and risk of cardiac arrhythmias in insulin-treated type 2 diabetes and controls

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. EDUCATION PROGRAMMES FOR PERSONS WITH TYPE 1 DIABETES USING AN INSULIN PUMP: A SYSTEMATIC REVIEW

    Research output: Contribution to journalReviewResearchpeer-review

  4. Cold-induced dishabituation in rodents exposed to recurrent hypoglycaemia

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

Context and Objective: Severe hypoglycemic events are unevenly distributed in subjects with type 1 diabetes making a genetic influence probable. The adrenergic beta-2-receptor gene (ADRB2) has several common polymorphisms of which the Arg16 allele is associated with receptor down-regulation and reduced agonist-mediated endogenous glucose production. We tested the hypothesis that the Arg16 variant is associated with severe hypoglycaemia.

Method: A cohort of 311 subjects with type 1 diabetes reported severe hypoglycemic events retrospectively in a validated questionnaire. The subjects were characterized by diabetes history, state of hypoglycemia awareness (Clarke, Gold, and Hillerød methods), C-peptide status, hemoglobin A1c (HbA1c), and ADRB2 genotype.

Results: The ADRB2 Gly16Arg genotype distribution was in Hardy-Weinberg equilibrium. There was a difference in rate of severe hypoglycemia between all genotypes (P=0.01). Subjects homozygous for the Arg16 genotype (AA, n=60) had a relative rate of severe hypoglycemia of 2.2 (CI95 1.3-3.6) compared to subjects homozygous for the Gly16 genotype (GG, n=116) (P=0.002). Among subjects with impaired awareness or unawareness (n=175) those with the AA genotype (n=33) had a relative rate of severe hypoglycemia of 3.2 (CI95 1.7-6.0) compared to subjects with the GG genotype (n=58) (P<0.000). Genotype was not associated with state of hypoglycemia awareness per se as assessed by any of three classification methods. The difference was not explained by other risk factors (duration of diabetes, HbA1c, C-peptide).

Conclusions: Genetic polymorphism in the beta-2-receptor gene is associated with risk of severe hypoglycemia in individuals with type 1 diabetes, especially in those with impaired hypoglycemia awareness.

Original languageEnglish
JournalThe Journal of clinical endocrinology and metabolism
Volume103
Issue number8
Pages (from-to)2901-2908
ISSN0021-972X
DOIs
Publication statusPublished - 2018

    Research areas

  • Journal Article

ID: 53793170