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Impact of enteral supplements enriched with omega-3 fatty acids and/or omega-6 fatty acids, arginine and ribonucleic acid compounds on leptin levels and nutritional status in active Crohn's disease treated with prednisolone.

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  • Aneta Aleksandra Nielsen
  • Jens Nederby Nielsen
  • Henning Grønbaek
  • Martin Eivindson
  • Ida Vind
  • Pia Munkholm
  • Ivan Brandslund
  • Henrik Hey
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BACKGROUND: Patients with Crohn's disease (CD) often develop malnutrition due to disease activity. We aimed to assess the effect of two different enteral supplements of Impact(R) Powder (IP; Novartis, Switzerland) on leptin levels and nutritional status in active CD patients during prednisolone treatment and tapering. METHODS: Thirty-one CD patients were randomized to IP Extra (group 1) or IP Standard (group 2). Leptin levels, nutritional, clinical and biochemical markers were studied at inclusion, after 5 and after 9 weeks of the study. RESULTS: Leptin levels, body mass index (BMI) and total cholesterol increased significantly within both groups at week 5 compared to inclusion. Leptin levels correlated with BMI in both groups at inclusion and in group 2 at week 9. In group 1, triglyceride levels remained unchanged, while levels in group 2 increased significantly at week 5 compared to inclusion. Clinical and biochemical markers improved during the study compared to inclusion. CONCLUSIONS: Increased leptin levels during the study progress were transient, decreasing due to prednisolone withdrawal at the end of the study. Both formulas used as adjuvant therapy to prednisolone treatment were able to improve nutritional status in CD patients.
Original languageEnglish
JournalDigestion
Volume75
Issue number1
Pages (from-to)10-6
Number of pages6
DOIs
Publication statusPublished - 2007

    Research areas

  • Adolescent, Adult, Aged, Arginine, Body Mass Index, Crohn Disease, Dietary Supplements, Double-Blind Method, Fatty Acids, Omega-3, Fatty Acids, Omega-6, Female, Glucocorticoids, Humans, Leptin, Male, Middle Aged, Nutritional Status, Prednisolone, RNA

ID: 32543040