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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Impact of COVID-19 Disruptions on Global BCG Coverage and Paediatric TB Mortality: A Modelling Study

Research output: Contribution to journalJournal articlepeer-review

DOI

  1. The Association of Low Vitamin K Status with Mortality in a Cohort of 138 Hospitalized Patients with COVID-19

    Research output: Contribution to journalJournal articlepeer-review

  • Nabila Shaikh
  • Puck T Pelzer
  • Sanne M Thysen
  • Partho Roy
  • Rebecca C Harris
  • Richard G White
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The impact of COVID-19 disruptions on global Bacillus Calmette-Guérin (BCG) coverage and paediatric tuberculosis (TB) mortality is still unknown. To fill this evidence-gap and guide mitigation measures, we estimated the impact of COVID-19 disruptions on global BCG coverage and paediatric TB mortality. First, we used data from multiple sources to estimate COVID-19-disrupted BCG vaccination coverage. Second, using a static mathematical model, we estimated the number of additional paediatric TB deaths in the first 15 years of life due to delayed/missed vaccinations in 14 scenarios-varying in duration of disruption, and magnitude and timing of catch-up. We estimated a 25% reduction in global BCG coverage within the disruption period. The best-case scenario (3-month disruption, 100% catch-up within 3 months) resulted in an additional 886 (0.5%) paediatric TB deaths, and the worst-case scenario (6-month disruption with no catch-up) resulted in an additional 33,074 (17%) deaths. The magnitude of catch-up was found to be the most influential variable in minimising excess paediatric TB mortality. Our results show that ensuring catch-up vaccination of missed children is a critical priority, and delivery of BCG alongside other routine vaccines may be a feasible way to achieve catch-up. Urgent action is required to support countries with recovering vaccination coverages to minimise paediatric deaths.

Original languageEnglish
Article number1228
JournalVaccines
Volume9
Issue number11
ISSN2076-393X
DOIs
Publication statusPublished - 22 Oct 2021

    Research areas

  • BCG, COVID-19, Immunization, Mathematical model, Paediatric mortality, Tuberculosis

ID: 69541699