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Impact analysis of rotavirus vaccination in various geographic regions in Western Europe

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Verberk, JDM, van Dongen, JAP, van de Kassteele, J, Andrews, NJ, van Gaalen, RD, Hahné, SJM, Vennema, H, Ramsay, M, Braeckman, T, Ladhani, S, Thomas, SL, Walker, JL, de Melker, HE, Fischer, TK, Koch, J & Bruijning-Verhagen, P 2021, 'Impact analysis of rotavirus vaccination in various geographic regions in Western Europe', Vaccine, vol. 39, no. 45, pp. 6671-6681. https://doi.org/10.1016/j.vaccine.2021.09.059

APA

Verberk, J. D. M., van Dongen, J. A. P., van de Kassteele, J., Andrews, N. J., van Gaalen, R. D., Hahné, S. J. M., Vennema, H., Ramsay, M., Braeckman, T., Ladhani, S., Thomas, S. L., Walker, J. L., de Melker, H. E., Fischer, T. K., Koch, J., & Bruijning-Verhagen, P. (2021). Impact analysis of rotavirus vaccination in various geographic regions in Western Europe. Vaccine, 39(45), 6671-6681. https://doi.org/10.1016/j.vaccine.2021.09.059

CBE

Verberk JDM, van Dongen JAP, van de Kassteele J, Andrews NJ, van Gaalen RD, Hahné SJM, Vennema H, Ramsay M, Braeckman T, Ladhani S, Thomas SL, Walker JL, de Melker HE, Fischer TK, Koch J, Bruijning-Verhagen P. 2021. Impact analysis of rotavirus vaccination in various geographic regions in Western Europe. Vaccine. 39(45):6671-6681. https://doi.org/10.1016/j.vaccine.2021.09.059

MLA

Vancouver

Verberk JDM, van Dongen JAP, van de Kassteele J, Andrews NJ, van Gaalen RD, Hahné SJM et al. Impact analysis of rotavirus vaccination in various geographic regions in Western Europe. Vaccine. 2021 Oct 29;39(45):6671-6681. https://doi.org/10.1016/j.vaccine.2021.09.059

Author

Verberk, J D M ; van Dongen, J A P ; van de Kassteele, J ; Andrews, N J ; van Gaalen, R D ; Hahné, S J M ; Vennema, H ; Ramsay, M ; Braeckman, T ; Ladhani, S ; Thomas, S L ; Walker, J L ; de Melker, H E ; Fischer, T K ; Koch, J ; Bruijning-Verhagen, P. / Impact analysis of rotavirus vaccination in various geographic regions in Western Europe. In: Vaccine. 2021 ; Vol. 39, No. 45. pp. 6671-6681.

Bibtex

@article{defd7adae5204c87958db1247de995da,
title = "Impact analysis of rotavirus vaccination in various geographic regions in Western Europe",
abstract = "BACKGROUND: Universal mass vaccination (UMV) against rotavirus has been implemented in many but not all European countries. This study investigated the impact of UMV on rotavirus incidence trends by comparing European countries with UMV: Belgium, England/Wales and Germany versus countries without UMV: Denmark and the Netherlands.METHODS: For this observational retrospective cohort study, time series data (2001-2016) on rotavirus detections, meteorological factors and population demographics were collected. For each country, several meteorological and population factors were investigated as possible predictors of rotavirus incidence. The final set of predictors were incorporated in negative binomial models accounting for seasonality and serial autocorrelation, and time-varying incidence rate ratios (IRR) were calculated for each age group and country separately. The overall vaccination impact two years after vaccine implementation was estimated by pooling the results using a random effects meta-analyses. Independent t-tests were used to compare annual epidemics in the pre-vaccination and post-vaccination era to explore any changes in the timing of rotavirus epidemics.RESULTS: The population size and several meteorological factors were predictors for the rotavirus epidemiology. Overall, we estimated a 42% (95%-CI 23;56%) reduction in rotavirus incidence attributable to UMV. Strongest reductions were observed for age-groups 0-, 1- and 2-years (IRR 0.47, 0.48 and 0.63, respectively). No herd effect induced by UMV in neighbouring countries was observed. In all UMV countries, the start and/or stop and corresponding peak of the rotavirus season was delayed by 4-7 weeks.CONCLUSIONS: The introduction of rotavirus UMV resulted in an overall reduction of 42% in rotavirus incidence in Western European countries two years after vaccine introduction and caused a change in seasonal pattern. No herd effect induced by UMV neighbouring countries was observed for Denmark and the Netherlands.",
keywords = "Gastroenteritis Rotavirus Vaccines Children Diarrhoea Europe Impact",
author = "Verberk, {J D M} and {van Dongen}, {J A P} and {van de Kassteele}, J and Andrews, {N J} and {van Gaalen}, {R D} and Hahn{\'e}, {S J M} and H Vennema and M Ramsay and T Braeckman and S Ladhani and Thomas, {S L} and Walker, {J L} and {de Melker}, {H E} and Fischer, {T K} and J Koch and P Bruijning-Verhagen",
note = "Copyright {\textcopyright} 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.",
year = "2021",
month = oct,
day = "29",
doi = "10.1016/j.vaccine.2021.09.059",
language = "English",
volume = "39",
pages = "6671--6681",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier Ltd",
number = "45",

}

RIS

TY - JOUR

T1 - Impact analysis of rotavirus vaccination in various geographic regions in Western Europe

AU - Verberk, J D M

AU - van Dongen, J A P

AU - van de Kassteele, J

AU - Andrews, N J

AU - van Gaalen, R D

AU - Hahné, S J M

AU - Vennema, H

AU - Ramsay, M

AU - Braeckman, T

AU - Ladhani, S

AU - Thomas, S L

AU - Walker, J L

AU - de Melker, H E

AU - Fischer, T K

AU - Koch, J

AU - Bruijning-Verhagen, P

N1 - Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2021/10/29

Y1 - 2021/10/29

N2 - BACKGROUND: Universal mass vaccination (UMV) against rotavirus has been implemented in many but not all European countries. This study investigated the impact of UMV on rotavirus incidence trends by comparing European countries with UMV: Belgium, England/Wales and Germany versus countries without UMV: Denmark and the Netherlands.METHODS: For this observational retrospective cohort study, time series data (2001-2016) on rotavirus detections, meteorological factors and population demographics were collected. For each country, several meteorological and population factors were investigated as possible predictors of rotavirus incidence. The final set of predictors were incorporated in negative binomial models accounting for seasonality and serial autocorrelation, and time-varying incidence rate ratios (IRR) were calculated for each age group and country separately. The overall vaccination impact two years after vaccine implementation was estimated by pooling the results using a random effects meta-analyses. Independent t-tests were used to compare annual epidemics in the pre-vaccination and post-vaccination era to explore any changes in the timing of rotavirus epidemics.RESULTS: The population size and several meteorological factors were predictors for the rotavirus epidemiology. Overall, we estimated a 42% (95%-CI 23;56%) reduction in rotavirus incidence attributable to UMV. Strongest reductions were observed for age-groups 0-, 1- and 2-years (IRR 0.47, 0.48 and 0.63, respectively). No herd effect induced by UMV in neighbouring countries was observed. In all UMV countries, the start and/or stop and corresponding peak of the rotavirus season was delayed by 4-7 weeks.CONCLUSIONS: The introduction of rotavirus UMV resulted in an overall reduction of 42% in rotavirus incidence in Western European countries two years after vaccine introduction and caused a change in seasonal pattern. No herd effect induced by UMV neighbouring countries was observed for Denmark and the Netherlands.

AB - BACKGROUND: Universal mass vaccination (UMV) against rotavirus has been implemented in many but not all European countries. This study investigated the impact of UMV on rotavirus incidence trends by comparing European countries with UMV: Belgium, England/Wales and Germany versus countries without UMV: Denmark and the Netherlands.METHODS: For this observational retrospective cohort study, time series data (2001-2016) on rotavirus detections, meteorological factors and population demographics were collected. For each country, several meteorological and population factors were investigated as possible predictors of rotavirus incidence. The final set of predictors were incorporated in negative binomial models accounting for seasonality and serial autocorrelation, and time-varying incidence rate ratios (IRR) were calculated for each age group and country separately. The overall vaccination impact two years after vaccine implementation was estimated by pooling the results using a random effects meta-analyses. Independent t-tests were used to compare annual epidemics in the pre-vaccination and post-vaccination era to explore any changes in the timing of rotavirus epidemics.RESULTS: The population size and several meteorological factors were predictors for the rotavirus epidemiology. Overall, we estimated a 42% (95%-CI 23;56%) reduction in rotavirus incidence attributable to UMV. Strongest reductions were observed for age-groups 0-, 1- and 2-years (IRR 0.47, 0.48 and 0.63, respectively). No herd effect induced by UMV in neighbouring countries was observed. In all UMV countries, the start and/or stop and corresponding peak of the rotavirus season was delayed by 4-7 weeks.CONCLUSIONS: The introduction of rotavirus UMV resulted in an overall reduction of 42% in rotavirus incidence in Western European countries two years after vaccine introduction and caused a change in seasonal pattern. No herd effect induced by UMV neighbouring countries was observed for Denmark and the Netherlands.

KW - Gastroenteritis Rotavirus Vaccines Children Diarrhoea Europe Impact

UR - http://www.scopus.com/inward/record.url?scp=85116775026&partnerID=8YFLogxK

U2 - 10.1016/j.vaccine.2021.09.059

DO - 10.1016/j.vaccine.2021.09.059

M3 - Journal article

C2 - 34635375

VL - 39

SP - 6671

EP - 6681

JO - Vaccine

JF - Vaccine

SN - 0264-410X

IS - 45

ER -

ID: 68207499