Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
E-pub ahead of print

Impact analysis of rotavirus vaccination in various geographic regions in Western Europe

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Recommendations for respiratory syncytial virus surveillance at the national level

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Distinct patterns of within-host virus populations between two subgroups of human respiratory syncytial virus

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Origins of SARS-CoV-2: window is closing for key scientific studies

    Research output: Contribution to journalComment/debateResearchpeer-review

  4. Molecular Epidemiology and Evolutionary Trajectory of Emerging Echovirus 30, Europe

    Research output: Contribution to journalJournal articleResearchpeer-review

  • J D M Verberk
  • J A P van Dongen
  • J van de Kassteele
  • N J Andrews
  • R D van Gaalen
  • S J M Hahné
  • H Vennema
  • M Ramsay
  • T Braeckman
  • S Ladhani
  • S L Thomas
  • J L Walker
  • H E de Melker
  • T K Fischer
  • J Koch
  • P Bruijning-Verhagen
View graph of relations

BACKGROUND: Universal mass vaccination (UMV) against rotavirus has been implemented in many but not all European countries. This study investigated the impact of UMV on rotavirus incidence trends by comparing European countries with UMV: Belgium, England/Wales and Germany versus countries without UMV: Denmark and the Netherlands.

METHODS: For this observational retrospective cohort study, time series data (2001-2016) on rotavirus detections, meteorological factors and population demographics were collected. For each country, several meteorological and population factors were investigated as possible predictors of rotavirus incidence. The final set of predictors were incorporated in negative binomial models accounting for seasonality and serial autocorrelation, and time-varying incidence rate ratios (IRR) were calculated for each age group and country separately. The overall vaccination impact two years after vaccine implementation was estimated by pooling the results using a random effects meta-analyses. Independent t-tests were used to compare annual epidemics in the pre-vaccination and post-vaccination era to explore any changes in the timing of rotavirus epidemics.

RESULTS: The population size and several meteorological factors were predictors for the rotavirus epidemiology. Overall, we estimated a 42% (95%-CI 23;56%) reduction in rotavirus incidence attributable to UMV. Strongest reductions were observed for age-groups 0-, 1- and 2-years (IRR 0.47, 0.48 and 0.63, respectively). No herd effect induced by UMV in neighbouring countries was observed. In all UMV countries, the start and/or stop and corresponding peak of the rotavirus season was delayed by 4-7 weeks.

CONCLUSIONS: The introduction of rotavirus UMV resulted in an overall reduction of 42% in rotavirus incidence in Western European countries two years after vaccine introduction and caused a change in seasonal pattern. No herd effect induced by UMV neighbouring countries was observed for Denmark and the Netherlands.

Original languageEnglish
JournalVaccine
Volume39
Issue number45
Pages (from-to)6671-6681
Number of pages11
ISSN0264-410X
DOIs
Publication statusE-pub ahead of print - 8 Oct 2021
Externally publishedYes

Bibliographical note

Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.

    Research areas

  • Gastroenteritis Rotavirus Vaccines Children Diarrhoea Europe Impact

ID: 68207499