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Immunterapi til patienter med malignt melanom og hjernemetastaser

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  1. Author Correction: Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melanoma

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  2. Author Correction: Tertiary lymphoid structures improve immunotherapy and survival in melanoma

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  3. CTLA-4 blockade boosts the expansion of tumor-reactive CD8+ tumor-infiltrating lymphocytes in ovarian cancer

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  4. Genome-wide CRISPR-Cas9 screening reveals ubiquitous T cell cancer targeting via the monomorphic MHC class I-related protein MR1

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  • Line Thing Simonsen
  • Anne Mette Sjørslev Schmidt
  • Trine Heide Øllegaard
  • Inge Marie Svane
  • Lars Bastholt
  • Adam Andrzej Luczak
  • Henrik Schmidt
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Melanoma has a high propensity to form brain metastases, and in this review, we discuss the treatment options for brain metastases. These have previously been sparse, but with the introduction of targeted therapy and checkpoint inhibitors, studies including patients with brain metastases have been published. Recent studies investigating combination of either dabrafenib and trametinib or ipilimumab and nivolumab have proved promising. Based on phase II studies, the most effective treatment for patients with asymptomatic brain metastases seems to be ipilimumab and nivolumab. Symptomatic brain metastases are presently being further investigated.

Translated title of the contributionImmunotherapy for patients with malignant melanoma and brain metastases
Original languageDanish
JournalUgeskrift for Laeger
Volume181
Issue number24
ISSN0041-5782
Publication statusPublished - 10 Jun 2019

ID: 57728547