Immunological detection of the type V collagen propeptide fragment, PVCP-1230, in connective tissue remodeling associated with liver fibrosis

Efstathios Vassiliadis; Sanne Skovgård Veidal; Henrik Simonsen; Dorthe Larsen; Ben Vainer; Xiaoliang Chen; Qinlong Zheng; Morten A Karsdal; Diana Julie Leeming

doi:10.3109/1354750X.2011.584131

Immunological detection of the type V collagen propeptide fragment, PVCP-1230, in connective tissue remodeling associated with liver fibrosis

Efstathios Vassiliadis, Sanne Skovgård Veidal, Henrik Simonsen, Dorthe Larsen, Ben Vainer, Xiaoliang Chen, Qinlong Zheng, Morten A Karsdal, Diana Julie Leeming

48 Citations (Scopus)

Abstract

Liver fibrosis involves excessive remodeling and deposition of fibrillar extracellular matrix (ECM) components, which leads to malfunction of the organ, causing significant morbidity and mortality. The aim of this study was to assess whether levels of a type V collagen fragment, the propeptide CO5-1230, indicate the amount of collagen deposited during liver fibrosis.

Original language	English
Journal	Biomarkers
Volume	16
Issue number	5
Pages (from-to)	426-33
Number of pages	8
ISSN	1354-750X
DOIs	https://doi.org/10.3109/1354750X.2011.584131
Publication status	Published - 2011

Keywords

Animals
Collagen Type V
Connective Tissue
Enzyme-Linked Immunosorbent Assay
Liver Cirrhosis
Male
Mice
Mice, Inbred BALB C
Peptide Fragments
Rats
Rats, Wistar
Reproducibility of Results

Access to Document

10.3109/1354750X.2011.584131

Cite this

@article{df2843c5fac64fec9e9ad9431d1d7821,

title = "Immunological detection of the type V collagen propeptide fragment, PVCP-1230, in connective tissue remodeling associated with liver fibrosis",

abstract = "Liver fibrosis involves excessive remodeling and deposition of fibrillar extracellular matrix (ECM) components, which leads to malfunction of the organ, causing significant morbidity and mortality. The aim of this study was to assess whether levels of a type V collagen fragment, the propeptide CO5-1230, indicate the amount of collagen deposited during liver fibrosis.",

keywords = "Animals, Collagen Type V, Connective Tissue, Enzyme-Linked Immunosorbent Assay, Liver Cirrhosis, Male, Mice, Mice, Inbred BALB C, Peptide Fragments, Rats, Rats, Wistar, Reproducibility of Results",

author = "Efstathios Vassiliadis and Veidal, \{Sanne Skovg{\aa}rd\} and Henrik Simonsen and Dorthe Larsen and Ben Vainer and Xiaoliang Chen and Qinlong Zheng and Karsdal, \{Morten A\} and Leeming, \{Diana Julie\}",

year = "2011",

doi = "10.3109/1354750X.2011.584131",

language = "English",

volume = "16",

pages = "426--33",

journal = "Biomarkers",

issn = "1354-750X",

publisher = "Taylor and Francis Ltd.",

number = "5",

}

TY - JOUR

T1 - Immunological detection of the type V collagen propeptide fragment, PVCP-1230, in connective tissue remodeling associated with liver fibrosis

AU - Vassiliadis, Efstathios

AU - Veidal, Sanne Skovgård

AU - Simonsen, Henrik

AU - Larsen, Dorthe

AU - Vainer, Ben

AU - Chen, Xiaoliang

AU - Zheng, Qinlong

AU - Karsdal, Morten A

AU - Leeming, Diana Julie

PY - 2011

Y1 - 2011

N2 - Liver fibrosis involves excessive remodeling and deposition of fibrillar extracellular matrix (ECM) components, which leads to malfunction of the organ, causing significant morbidity and mortality. The aim of this study was to assess whether levels of a type V collagen fragment, the propeptide CO5-1230, indicate the amount of collagen deposited during liver fibrosis.

AB - Liver fibrosis involves excessive remodeling and deposition of fibrillar extracellular matrix (ECM) components, which leads to malfunction of the organ, causing significant morbidity and mortality. The aim of this study was to assess whether levels of a type V collagen fragment, the propeptide CO5-1230, indicate the amount of collagen deposited during liver fibrosis.

KW - Animals

KW - Collagen Type V

KW - Connective Tissue

KW - Enzyme-Linked Immunosorbent Assay

KW - Liver Cirrhosis

KW - Male

KW - Mice

KW - Mice, Inbred BALB C

KW - Peptide Fragments

KW - Rats

KW - Rats, Wistar

KW - Reproducibility of Results

UR - https://www.scopus.com/pages/publications/79960788301

U2 - 10.3109/1354750X.2011.584131

DO - 10.3109/1354750X.2011.584131

M3 - Journal article

C2 - 21612338

SN - 1354-750X

VL - 16

SP - 426

EP - 433

JO - Biomarkers

JF - Biomarkers

IS - 5

ER -

Immunological detection of the type V collagen propeptide fragment, PVCP-1230, in connective tissue remodeling associated with liver fibrosis

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this