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Immunoglobulin with High-Titer In Vitro Cross-Neutralizing Hepatitis C Virus Antibodies Passively Protects Chimpanzees from Homologous, but Not Heterologous, Challenge

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DOI

  1. Replicons of a rodent hepatitis C model virus permit selection of highly permissive cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. IDENTIFICATION OF PIPERAZINYLBENZENESULFONAMIDES AS NEW INHIBITORS OF CLAUDIN-1 TRAFFICKING AND HEPATITIS C VIRUS ENTRY

    Research output: Contribution to journalJournal articleResearchpeer-review

  1. Ribavirin inhibition of cell-culture infectious hepatitis C genotype 1-3 viruses is strain-dependent

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Genome Sequence of an Unknown Subtype of Hepatitis C Virus Genotype 6: Another Piece for the Taxonomic Puzzle

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  3. Virus Adaptation and Selection Following Challenge of Animals Vaccinated against Classical Swine Fever Virus

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. HCV p7 as a novel vaccine-target inducing multifunctional CD4+ and CD8+ T-cells targeting liver cells expressing the viral antigen

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Replicons of a rodent hepatitis C model virus permit selection of highly permissive cells

    Research output: Contribution to journalJournal articleResearchpeer-review

  • Jens Bukh
  • Ronald E Engle
  • Kristina Faulk
  • Richard Y Wang
  • Patrizia Farci
  • Harvey J Alter
  • Robert H Purcell
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The importance of neutralizing antibodies (NAbs) in protection against hepatitis C virus (HCV) remains controversial. We infused a chimpanzee with H06 immunoglobulin from a genotype 1a HCV-infected patient and challenged with genotype strains efficiently neutralized by H06 in vitro. Genotype 1a NAbs afforded no protection against genotype 4a or 5a. Protection against homologous 1a lasted 18 weeks, but infection emerged when NAb titers waned. However, 6a infection was prevented. The differential in vivo neutralization patterns have implications for HCV vaccine development.

Original languageEnglish
JournalJournal of Virology
Volume89
Issue number17
Pages (from-to)9128-32
Number of pages5
ISSN0022-538X
DOIs
Publication statusPublished - 1 Sep 2015

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