Immunofluorescent Analysis of Testicular Biopsies with Germ Cell and Sertoli Cell Markers Shows Significant MVH Negative Germ Cell Depletion with Older Age at Orchiopexy

Ruili Li; Jorgen Thorup; Cong Sun; Dina Cortes; Bridget Southwell; John Hutson

doi:10.1016/j.juro.2013.08.075

Immunofluorescent Analysis of Testicular Biopsies with Germ Cell and Sertoli Cell Markers Shows Significant MVH Negative Germ Cell Depletion with Older Age at Orchiopexy

Ruili Li, Jorgen Thorup, Cong Sun, Dina Cortes, Bridget Southwell, John Hutson

Department of Pediatrics

25 Citations (Scopus)

Abstract

Undescended testis is the most common defect in male newborns. This condition is associated with increased risks of infertility and testicular malignancy due to abnormal germ cell development in the testes. Early surgery may limit such risks. We analyzed germ cell development vs age at orchiopexy using a germ cell marker and a Sertoli cell marker on testicular biopsies.

Original language	English
Journal	The Journal of urology
Volume	191
Issue number	2
Pages (from-to)	458-464
ISSN	0022-5347
DOIs	https://doi.org/10.1016/j.juro.2013.08.075
Publication status	Published - Feb 2014

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Immunofluorescent Analysis of Testicular Biopsies with Germ Cell and Sertoli Cell Markers Shows Significant MVH Negative Germ Cell Depletion with Older Age at Orchiopexy. / Li, Ruili; Thorup, Jorgen; Sun, Cong et al.
In: The Journal of urology, Vol. 191, No. 2, 02.2014, p. 458-464.

Research output: Contribution to journal › Journal article › Research › peer-review

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abstract = "Undescended testis is the most common defect in male newborns. This condition is associated with increased risks of infertility and testicular malignancy due to abnormal germ cell development in the testes. Early surgery may limit such risks. We analyzed germ cell development vs age at orchiopexy using a germ cell marker and a Sertoli cell marker on testicular biopsies.",

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AU - Cortes, Dina

AU - Southwell, Bridget

AU - Hutson, John

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AB - Undescended testis is the most common defect in male newborns. This condition is associated with increased risks of infertility and testicular malignancy due to abnormal germ cell development in the testes. Early surgery may limit such risks. We analyzed germ cell development vs age at orchiopexy using a germ cell marker and a Sertoli cell marker on testicular biopsies.

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Immunofluorescent Analysis of Testicular Biopsies with Germ Cell and Sertoli Cell Markers Shows Significant MVH Negative Germ Cell Depletion with Older Age at Orchiopexy

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