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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Immune cells and prognosis in HPV-associated oropharyngeal squamous cell carcinomas: Review of the literature

Research output: Contribution to journalJournal articleResearchpeer-review

  1. Nasopharyngeal malignancies in Denmark diagnosed from 1980 to 2014

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Association between human papillomavirus status and health-related quality of life in oropharyngeal and oral cavity cancer survivors

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Comorbidity in HPV+ and HPV- oropharyngeal cancer patients: A population-based, case-control study

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. The effects of checkpoint inhibition on head and neck squamous cell carcinoma: A systematic review

    Research output: Contribution to journalReviewResearchpeer-review

  1. Genomic Alterations in Human Papillomavirus-Positive and -Negative Conjunctival Squamous Cell Carcinomas

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Nasopharyngeal malignancies in Denmark diagnosed from 1980 to 2014

    Research output: Contribution to journalJournal articleResearchpeer-review

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Currently, oropharyngeal squamous cell carcinomas (OPSCC) are treated based on the traditional TNM-classification, although this scheme might be inadequate for the subgroup of human papillomavirus (HPV)-associated OPSCCs. It remains debatable whether this subgroup of patients with favorable prognosis should be offered altered treatment. Besides the well-known biomarkers of HPV and p16, new promising immune cells and markers might nuance the prognosis and treatment for patients with HPV+ OPSCC. We systematically reviewed the literature on immunological features of HPV-associated OPSCCs, and report that a high number of cytotoxic T cells (CD8s) and a low number of CD98 positive cells is associated with better outcome, while an increased CD4/CD8 ratio and a high human leukocyte antigen 1 (HLA1) intensity is most likely associated with worse outcome. These findings might contribute to future OPSCC staging and treatment.

Original languageEnglish
JournalOral Oncology
Volume58
Pages (from-to)8-13
Number of pages6
ISSN1368-8375
DOIs
Publication statusPublished - Jul 2016

    Research areas

  • Journal Article, Review

ID: 49659640