Research
Print page Print page
Switch language
The Capital Region of Denmark - a part of Copenhagen University Hospital
Published

Imaging brain microstructure with diffusion MRI: practicality and applications

Research output: Contribution to journalReviewResearchpeer-review

DOI

  1. (1) H-MRS processing parameters affect metabolite quantification: The urgent need for uniform and transparent standardization

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Effect of paramagnetic manganese cations on (1)H MRS of the brain

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. In vivo quantitation of metabolite concentrations in the brain by means of proton MRS.

    Research output: Contribution to journalReviewResearch

  4. Signal changes in gradient echo images of human brain induced by hypo- and hyperoxia.

    Research output: Contribution to journalJournal articleResearch

  1. Multidimensional diffusion MRI with spectrally modulated gradients reveals unprecedented microstructural detail

    Research output: Contribution to journalJournal articleResearchpeer-review

  2. Muscle fibre morphology and microarchitecture in cerebral palsy patients obtained by 3D synchrotron X-ray computed tomography

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Diversity of Cortico-descending Projections: Histological and Diffusion MRI Characterization in the Monkey

    Research output: Contribution to journalJournal articleResearchpeer-review

View graph of relations

This article gives an overview of microstructure imaging of the brain with diffusion MRI and reviews the state of the art. The microstructure-imaging paradigm aims to estimate and map microscopic properties of tissue using a model that links these properties to the voxel scale MR signal. Imaging techniques of this type are just starting to make the transition from the technical research domain to wide application in biomedical studies. We focus here on the practicalities of both implementing such techniques and using them in applications. Specifically, the article summarizes the relevant aspects of brain microanatomy and the range of diffusion-weighted MR measurements that provide sensitivity to them. It then reviews the evolution of mathematical and computational models that relate the diffusion MR signal to brain tissue microstructure, as well as the expanding areas of application. Next we focus on practicalities of designing a working microstructure imaging technique: model selection, experiment design, parameter estimation, validation, and the pipeline of development of this class of technique. The article concludes with some future perspectives on opportunities in this topic and expectations on how the field will evolve in the short-to-medium term.

Original languageEnglish
Article numbere3841
JournalN M R in Biomedicine
Volume32
Issue number4
Pages (from-to)e3841
ISSN0952-3480
DOIs
Publication statusPublished - Apr 2019

    Research areas

  • Journal Article, quantitative imaging, magnetic resonance imaging, diffusion MRI, microstructure imaging, virtual histology, brain, neuroimaging

ID: 52090544