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Identifying New Antimigraine Targets: Lessons from Molecular Biology

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@article{1fad31db6062463ea4d67c2ba05b817f,
title = "Identifying New Antimigraine Targets: Lessons from Molecular Biology",
abstract = "Primary headaches are one of the most common conditions; migraine being most prevalent. Recent work on the pathophysiology of migraine suggests a mismatch in the communication or tuning of the trigeminovascular system, leading to sensitization and the release of calcitonin gene-related peptide (CGRP). In the current Opinion, we use the up-to-date molecular understanding of mechanisms behind migraine pain, to provide novel aspects on how to modify the system and for the development of future treatments; acute as well as prophylactic. We explore the distribution and the expression of neuropeptides themselves, as well as certain ion channels, and most importantly how they may act in concert as modulators of excitability of both the trigeminal C neurons and the Aδ neurons.",
keywords = "C fibers, calcitonin gene-related peptide, node of Ranvier, Aδ fibers, trigeminovascular system, G-protein coupled receptors",
author = "Lars Edvinsson and Haanes, {Kristian Agmund}",
note = "Copyright {\textcopyright} 2021 Elsevier Ltd. All rights reserved.",
year = "2021",
month = apr,
doi = "10.1016/j.tips.2021.01.002",
language = "English",
volume = "42",
pages = "217--225",
journal = "Trends in Pharmacological Sciences",
issn = "0165-6147",
publisher = "Elsevier Ltd. Trends Journals",
number = "4",

}

RIS

TY - JOUR

T1 - Identifying New Antimigraine Targets

T2 - Lessons from Molecular Biology

AU - Edvinsson, Lars

AU - Haanes, Kristian Agmund

N1 - Copyright © 2021 Elsevier Ltd. All rights reserved.

PY - 2021/4

Y1 - 2021/4

N2 - Primary headaches are one of the most common conditions; migraine being most prevalent. Recent work on the pathophysiology of migraine suggests a mismatch in the communication or tuning of the trigeminovascular system, leading to sensitization and the release of calcitonin gene-related peptide (CGRP). In the current Opinion, we use the up-to-date molecular understanding of mechanisms behind migraine pain, to provide novel aspects on how to modify the system and for the development of future treatments; acute as well as prophylactic. We explore the distribution and the expression of neuropeptides themselves, as well as certain ion channels, and most importantly how they may act in concert as modulators of excitability of both the trigeminal C neurons and the Aδ neurons.

AB - Primary headaches are one of the most common conditions; migraine being most prevalent. Recent work on the pathophysiology of migraine suggests a mismatch in the communication or tuning of the trigeminovascular system, leading to sensitization and the release of calcitonin gene-related peptide (CGRP). In the current Opinion, we use the up-to-date molecular understanding of mechanisms behind migraine pain, to provide novel aspects on how to modify the system and for the development of future treatments; acute as well as prophylactic. We explore the distribution and the expression of neuropeptides themselves, as well as certain ion channels, and most importantly how they may act in concert as modulators of excitability of both the trigeminal C neurons and the Aδ neurons.

KW - C fibers

KW - calcitonin gene-related peptide

KW - node of Ranvier, Aδ fibers

KW - trigeminovascular system, G-protein coupled receptors

UR - http://www.scopus.com/inward/record.url?scp=85099971292&partnerID=8YFLogxK

U2 - 10.1016/j.tips.2021.01.002

DO - 10.1016/j.tips.2021.01.002

M3 - Review

C2 - 33495027

VL - 42

SP - 217

EP - 225

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

SN - 0165-6147

IS - 4

ER -

ID: 62406431