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The Capital Region of Denmark - a part of Copenhagen University Hospital
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Identifying New Antimigraine Targets: Lessons from Molecular Biology

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  1. High progesterone levels during the luteal phase related to the use of an aromatase inhibitor in breast cancer patients

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  2. Novel Targeted Therapies for Inflammatory Bowel Disease

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  3. Heteromeric α7β2 Nicotinic Acetylcholine Receptors in the Brain

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  4. Emerging migraine treatments and drug targets

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  5. Interstitial cells of Cajal as targets for pharmacological intervention in gastrointestinal motor disorders

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  1. Hormonal influences in migraine - interactions of oestrogen, oxytocin and CGRP

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  2. CGRP and migraine; from bench to bedside

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  3. Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

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Primary headaches are one of the most common conditions; migraine being most prevalent. Recent work on the pathophysiology of migraine suggests a mismatch in the communication or tuning of the trigeminovascular system, leading to sensitization and the release of calcitonin gene-related peptide (CGRP). In the current Opinion, we use the up-to-date molecular understanding of mechanisms behind migraine pain, to provide novel aspects on how to modify the system and for the development of future treatments; acute as well as prophylactic. We explore the distribution and the expression of neuropeptides themselves, as well as certain ion channels, and most importantly how they may act in concert as modulators of excitability of both the trigeminal C neurons and the Aδ neurons.

Original languageEnglish
JournalTrends in Pharmacological Sciences
Volume42
Issue number4
Pages (from-to)217-225
Number of pages9
ISSN0165-6147
DOIs
Publication statusPublished - Apr 2021

    Research areas

  • C fibers, calcitonin gene-related peptide, node of Ranvier, Aδ fibers, trigeminovascular system, G-protein coupled receptors

ID: 62406431